The Vallecas Project: a cohort to identify early markers and mechanisms of Alzheimer's disease

Javier Olazaran*, Meritxell Valenti, Belen Frades, Maria Ascension Zea-Sevilla, Marina Avila-Villanueva, Miguel Angel Fernandez-Blazquez, Miguel Calero, Jose Luis Dobato, Juan Antonio Hernandez-Tamames, Beatriz Leon-Salas, Luis Agueera-Ortiz, Jorge Lopez-Alvarez, Pedro Larranaga, Concha Bielza, Juan Alvarez-Linera, Pablo Martinez-Martin

*Corresponding author for this work

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25 Citations (Scopus)
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Abstract

Introduction: Alzheimer's disease (AD) is a major threat for the well-being of an increasingly aged world population. The physiopathological mechanisms of late-onset AD are multiple, possibly heterogeneous, and not well understood. Different combinations of variables from several domains (i.e., clinical, neuropsychological, structural, and biochemical markers) may predict dementia conversion, according to distinct physiopathological pathways, in different groups of subjects.Methods: We launched the Vallecas Project (VP), a cohort study of non-demented people aged 70-85, to characterize the social, clinical, neuropsychological, structural, and biochemical underpinnings of AD inception. Given the exploratory nature of the VP, multidimensional and machine learning techniques will be applied, in addition to the traditional multivariate statistical methods.Results: A total of 1169 subjects were recruited between October 2011 and December 2013. Mean age was 74.4 years (SD 3.9), 63.5% of the subjects were women, and 17.9% of the subjects were carriers of at least one epsilon 4 allele of the apolipoprotein E gene. Cognitive diagnoses at inclusion were as follows: normal cognition 93.0% and mild cognitive impairment (MCI) 7.0% (3.1% amnestic MCI, 0.1% non-amnestic MCI, 3.8% mixed MCI). Blood samples were obtained and stored for future determinations in 99.9% of the subjects and 3T magnetic resonance imaging study was conducted in 89.9% of the volunteers. The cohort is being followed up annually for 4 years after the baseline.Conclusion: We have established a valuable homogeneous single-center cohort which, by identifying groups of variables associated with high risk of MCI or dementia conversion, should help to clarify the early physiopathological mechanisms of AD and should provide avenues for prompt diagnosis and AD prevention.
Original languageEnglish
Article number00181
Number of pages10
JournalFrontiers in Aging Neuroscience
Volume7
Issue numberSEP
DOIs
Publication statusPublished - 30 Sept 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 Olazarán, Valentí, Frades, Zea-Sevilla, ávila-Villanueva, Fernández-Blázquez, Calero, Dobato, Hernández-Tamames, León-Salas, Agüera-Ortiz, López-álvarez, Larrañaga, Bielza, álvarez-Linera and Martínez-Martín.

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