Therapeutic anticoagulation for splanchnic vein thrombosis in acute pancreatitis: A national survey and case-vignette study

Noor J. Sissingh, Jesse V. Groen, Hester C. Timmerhuis, Marc G. Besselink, Bas Boekestijn, Thomas L. Bollen, Bert A. Bonsing, Frederikus A. Klok, Hjalmar C. van Santvoort, Robert C. Verdonk, Casper H.J. van Eijck, Jeanin E. van Hooft, Jan Sven D. Mieog

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
25 Downloads (Pure)

Abstract

BACKGROUND: Splanchnic vein thrombosis (SVT) is a major complication of moderate and severe acute pancreatitis. There is no consensus on whether therapeutic anticoagulation should be started in patients with acute pancreatitis and SVT. AIM: To gain insight into current opinions and clinical decision making of pancreatologists regarding SVT in acute pancreatitis. METHODS: A total of 139 pancreatologists of the Dutch Pancreatitis Study Group and Dutch Pancreatic Cancer Group were approached to complete an online survey and case vignette survey. The threshold to assume group agreement was set at 75%. RESULTS: The response rate was 67% (n = 93). Seventy-one pancreatologists (77%) regularly prescribed therapeutic anticoagulation in case of SVT, and 12 pancreatologists (13%) for narrowing of splanchnic vein lumen. The most common reason to treat SVT was to avoid complications (87%). Acute thrombosis was the most important factor to prescribe therapeutic anticoagulation (90%). Portal vein thrombosis was chosen as the most preferred location to initiate therapeutic anticoagulation (76%) and splenic vein thrombosis as the least preferred location (86%). The preferred initial agent was low molecular weight heparin (LMWH; 87%). In the case vignettes, therapeutic anticoagulation was prescribed for acute portal vein thrombosis, with or without suspected infected necrosis (82% and 90%), and thrombus progression (88%). Agreement was lacking regarding the selection and duration of long-term anticoagulation, the indication for thrombophilia testing and upper endoscopy, and about whether risk of bleeding is a major barrier for therapeutic anticoagulation. CONCLUSION: In this national survey, the pancreatologists seemed to agree on the use of therapeutic anticoagulation, using LMWH in the acute phase, for acute portal thrombosis and in the case of thrombus progression, irrespective of the presence of infected necrosis.

Original languageEnglish
Pages (from-to)3328-3340
Number of pages13
JournalWorld Journal of Gastroenterology
Volume29
Issue number21
DOIs
Publication statusPublished - 7 Jun 2023

Bibliographical note

Funding Information:
We are very grateful to all 93 pancreatologists who participated in this study, 54 of whom agreed to be included in the acknowledgement: M Anten; A Bhalla; M Boermeester; K Bosscha; S Bouwense; H Braat; M Bruno; F van Delft; W Derksen; L van Driel; P van Duijvendijk; P Dura; R Eichhorn; P Fockens; E van Geenen; M Hadithi; M van der Have; J Haveman; M Hemmink; I de Hingh; H Hofker; L Holl; A Inderson; J Jansen; M Liem; D Lips; L Kager; V de Meijer; M Meijssen; H Moeniralam; V Nieuwenhuijs; M van de Poll; R Quispel; T Romkens; J Schreinemakers; M Schwartz; M Spanier; J Sprakel; M Stommel; J Straathof; J Tenthof van Noorden; W Thijs; M Tielemans; N Venneman; R Verbeek; F Vleggaar; R Voermans; J Vrolijk; L van der Waaij; R van Wanrooij; M Wielenga; R de Wilde; R Zoutendijk.

Publisher Copyright:
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.

Fingerprint

Dive into the research topics of 'Therapeutic anticoagulation for splanchnic vein thrombosis in acute pancreatitis: A national survey and case-vignette study'. Together they form a unique fingerprint.

Cite this