Therapeutic applications of thyroid hormone analogues

W. E. Visser

doi:10.1016/j.ando.2020.03.004

Therapeutic applications of thyroid hormone analogues

W. E. Visser

Internal Medicine

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

141 Downloads (Pure)

Abstract

Cellular thyroid hormone homeostasis requires adequate function of: (1) thyroid hormone transporter proteins at the plasma membrane, (2) deiodinating enzymes and (3) nuclear thyroid hormone receptors (TRs). Defects in any of these processes give rise to distinct disease entities, collectively called thyroid hormone signaling disorders. Thyroid hormone analogues hold therapeutic potential in thyroid hormone signaling disorders by bypassing defective transporters or binding to mutant TRs. This review will focus on the application of analogues in thyroid hormone signaling disorders, particularly monocarboxylate transporter (MCT)8 deficiency, and resistance to thyroid hormone due to mutations in TRβ (RTHβ)

Original language	English
Pages (from-to)	170-172
Number of pages	3
Journal	Annales d'Endocrinologie
Volume	82
Issue number	3-4
DOIs	https://doi.org/10.1016/j.ando.2020.03.004
Publication status	Published - Jun 2021

Bibliographical note

Funding Information:
This research was funded by the Netherlands Organisation for Health Research and Development (project number 113303005; to WEV), the Sherman Foundation (to WEV).

Publisher Copyright:
© 2020

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10.1016/j.ando.2020.03.004

Therapeutic-applications-of-thyroid-hormone-analo_2021_Annales-d-EndocrinoloFinal published version, 429 KBLicence: Unspecified

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Therapeutic applications of thyroid hormone analogues

Abstract

Bibliographical note

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