Therapeutic drug monitoring in oncology: International Association of Therapeutic Drug Monitoring and Clinical Toxicology consensus guidelines for imatinib therapy

William A. Clarke*, Etienne Chatelut, Alan K. Fotoohi, Richard A. Larson, Jennifer H. Martin, Ron H.J. Mathijssen, Salvatore J. Salamone

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

45 Citations (Scopus)

Abstract

Although therapeutic drug monitoring (TDM) is an important tool in guiding drug dosing for other areas of medicine including infectious diseases, cardiology, psychiatry and transplant medicine, it has not gained wide acceptance in oncology. For imatinib and other tyrosine kinase inhibitors, a flat dosing approach is utilised for management of oral chemotherapy. There are many published studies examining the correlation of blood concentrations with clinical effects of imatinib. The International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) determined that there was a need to examine the published literature regarding utility of TDM in imatinib therapy and to develop consensus guidelines for TDM based on the available data. This article summarises the scientific evidence regarding TDM of imatinib, as well as the consensus guidelines developed by the IATDMCT.

Original languageEnglish
Pages (from-to)428-440
Number of pages13
JournalEuropean Journal of Cancer
Volume157
DOIs
Publication statusPublished - Nov 2021

Bibliographical note

Funding Information:
The authors thank Jan Beumer, Gareth Veal, Teun van Gelder and Azucena Aldaz Pastor for their helpful comments during the course of finalising the manuscript, as well as the IATDMCT Oncology TDM Scientific Committee for their support of the guideline process.

Publisher Copyright:
© 2021

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