Therapie bij sympathische reflexdystrofie: Een systematisch overzicht

Translated title of the contribution: Treatment of Complex Regional Pain Syndrome type 1: A systematic review

PJ (Pieter) van den Berg*, Sita Bierma-Zeinstra, Bart Koes

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

2 Citations (Scopus)


Introduction: Although the Complex Regional Pain Syndrome (CRPS) has been described in the literature for more than a century, there are still doubts about the effectiveness of therapeutic interventions. This systematic review aims at summarising the existing evidence on therapeutic interventions in CRPS type 1. Methods: We conducted a systematic literature search in Medline and the Cochrane Controlled Trial Register. All studies describing a therapeutic intervention were eligible for inclusion in this review if (a) they used a control group, (b) described a pain-related endpoint and (c) were written in English, French, German or Dutch. The quality of the studies was assessed independently by two investigators using the Delphi list for randomised controlled trials (RCTs) and a self-developed list for crossover studies. A best-evidence synthesis was constructed using all studies chosen. Results: We included 28 studies, including 16 RCTs, 7 of the latter being considered to be of good quality. None of the 19 interventions described was convincingly proved to be effective. The majority of interventions (12/19) were reported in one study only. Conclusion: The debate on therapeutic interventions will continue unless the importance of performing controlled studies is recognised. In the meantime, as before, patients and physicians face the prospect of being involved with potentially ineffective treatments.

Translated title of the contributionTreatment of Complex Regional Pain Syndrome type 1: A systematic review
Original languageDutch
Pages (from-to)166-171
Number of pages6
JournalHuisarts en Wetenschap
Issue number4
Publication statusPublished - 10 Apr 2002


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