Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Cathy E Elks; John R B Perry; Patrick Sulem; Daniel I Chasman; Nora Franceschini; Chunyan He; Kathryn L Lunetta; Jenny A Visser; Enda M Byrne; Diana L Cousminer; Daniel F Gudbjartsson; Tõnu Esko; Bjarke Feenstra; GIANT Consortium; Jouke-Jan Hottenga; Daniel L Koller; Zoltán Kutalik; Peng Lin; Massimo Mangino; Mara Marongiu; Patrick F McArdle; Albert V Smith; Lisette Stolk; Sophie H van Wingerden; Jing Hua Zhao; Eva Albrecht; Tanguy Corre; Erik Ingelsson; Caroline Hayward; Patrik K E Magnusson; Erin N Smith; Shelia Ulivi; Nicole M Warrington; Lina Zgaga; Helen Alavere; Najaf Amin; Thor Aspelund; Stefania Bandinelli; Inês Barroso; Gerald S Berenson; Sven Bergmann; Hannah Blackburn; Eric Boerwinkle; Albert Hofman; Peter Kraft; Joop S E Laven; Ben A Oostra; Fernando Rivadeneira; Joyce B J van Meurs; Cornelia M van Duijn; André G Uitterlinden

doi:10.1038/ng.714

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Cathy E Elks, John R B Perry, Patrick Sulem, Daniel I Chasman, Nora Franceschini, Chunyan He, Kathryn L Lunetta, Jenny A Visser, Enda M Byrne, Diana L Cousminer, Daniel F Gudbjartsson, Tõnu Esko, Bjarke Feenstra, GIANT Consortium, Jouke-Jan Hottenga, Daniel L Koller, Zoltán Kutalik, Peng Lin, Massimo Mangino, Mara MarongiuPatrick F McArdle, Albert V Smith, Lisette Stolk, Sophie H van Wingerden, Jing Hua Zhao, Eva Albrecht, Tanguy Corre, Erik Ingelsson, Caroline Hayward, Patrik K E Magnusson, Erin N Smith, Shelia Ulivi, Nicole M Warrington, Lina Zgaga, Helen Alavere, Najaf Amin, Thor Aspelund, Stefania Bandinelli, Inês Barroso, Gerald S Berenson, Sven Bergmann, Hannah Blackburn, Eric Boerwinkle, Albert Hofman, Peter Kraft, Joop S E Laven, Ben A Oostra, Fernando Rivadeneira, Joyce B J van Meurs, Cornelia M van Duijn, André G Uitterlinden

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 x 10(-60)) and 9q31.2 (P = 2.2 x 10(-33)), we identified 30 new menarche loci (all P < 5 x 10(-8)) and found suggestive evidence for a further 10 loci (P < 1.9 x 10(-6)). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.

Original language	English
Pages (from-to)	1077-1085
Number of pages	9
Journal	Nature Genetics
Volume	42
Issue number	12
DOIs	https://doi.org/10.1038/ng.714
Publication status	Published - Dec 2010

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http://hdl.handle.net/1765/28342

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Elks, C. E., Perry, J. R. B., Sulem, P., Chasman, D. I., Franceschini, N., He, C., Lunetta, K. L., Visser, J. A., Byrne, E. M., Cousminer, D. L., Gudbjartsson, D. F., Esko, T., Feenstra, B., GIANT Consortium, Hottenga, J-J., Koller, D. L., Kutalik, Z., Lin, P., Mangino, M., ... Uitterlinden, A. G. (2010). Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nature Genetics, 42(12), 1077-1085. https://doi.org/10.1038/ng.714

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title = "Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies",

abstract = "To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 x 10(-60)) and 9q31.2 (P = 2.2 x 10(-33)), we identified 30 new menarche loci (all P < 5 x 10(-8)) and found suggestive evidence for a further 10 loci (P < 1.9 x 10(-6)). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.",

author = "Elks, {Cathy E} and Perry, {John R B} and Patrick Sulem and Chasman, {Daniel I} and Nora Franceschini and Chunyan He and Lunetta, {Kathryn L} and Visser, {Jenny A} and Byrne, {Enda M} and Cousminer, {Diana L} and Gudbjartsson, {Daniel F} and T{\~o}nu Esko and Bjarke Feenstra and {GIANT Consortium} and Jouke-Jan Hottenga and Koller, {Daniel L} and Zolt{\'a}n Kutalik and Peng Lin and Massimo Mangino and Mara Marongiu and McArdle, {Patrick F} and Smith, {Albert V} and Lisette Stolk and {van Wingerden}, {Sophie H} and Zhao, {Jing Hua} and Eva Albrecht and Tanguy Corre and Erik Ingelsson and Caroline Hayward and Magnusson, {Patrik K E} and Smith, {Erin N} and Shelia Ulivi and Warrington, {Nicole M} and Lina Zgaga and Helen Alavere and Najaf Amin and Thor Aspelund and Stefania Bandinelli and In{\^e}s Barroso and Berenson, {Gerald S} and Sven Bergmann and Hannah Blackburn and Eric Boerwinkle and Albert Hofman and Peter Kraft and Laven, {Joop S E} and Oostra, {Ben A} and Fernando Rivadeneira and {van Meurs}, {Joyce B J} and {van Duijn}, {Cornelia M} and Uitterlinden, {Andr{\'e} G}",

year = "2010",

month = dec,

doi = "10.1038/ng.714",

language = "English",

volume = "42",

pages = "1077--1085",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "12",

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Elks, CE, Perry, JRB, Sulem, P, Chasman, DI, Franceschini, N, He, C, Lunetta, KL, Visser, JA, Byrne, EM, Cousminer, DL, Gudbjartsson, DF, Esko, T, Feenstra, B, GIANT Consortium, Hottenga, J-J, Koller, DL, Kutalik, Z, Lin, P, Mangino, M, Marongiu, M, McArdle, PF, Smith, AV, Stolk, L, van Wingerden, SH, Zhao, JH, Albrecht, E, Corre, T, Ingelsson, E, Hayward, C, Magnusson, PKE, Smith, EN, Ulivi, S, Warrington, NM, Zgaga, L, Alavere, H, Amin, N, Aspelund, T, Bandinelli, S, Barroso, I, Berenson, GS, Bergmann, S, Blackburn, H, Boerwinkle, E, Hofman, A, Kraft, P, Laven, JSE, Oostra, BA, Rivadeneira, F , van Meurs, JBJ, van Duijn, CM & Uitterlinden, AG 2010, 'Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies', Nature Genetics, vol. 42, no. 12, pp. 1077-1085. https://doi.org/10.1038/ng.714

TY - JOUR

T1 - Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

AU - Elks, Cathy E

AU - Perry, John R B

AU - Sulem, Patrick

AU - Chasman, Daniel I

AU - Franceschini, Nora

AU - He, Chunyan

AU - Lunetta, Kathryn L

AU - Visser, Jenny A

AU - Byrne, Enda M

AU - Cousminer, Diana L

AU - Gudbjartsson, Daniel F

AU - Esko, Tõnu

AU - Feenstra, Bjarke

AU - GIANT Consortium

AU - Hottenga, Jouke-Jan

AU - Koller, Daniel L

AU - Kutalik, Zoltán

AU - Lin, Peng

AU - Mangino, Massimo

AU - Marongiu, Mara

AU - McArdle, Patrick F

AU - Smith, Albert V

AU - Stolk, Lisette

AU - van Wingerden, Sophie H

AU - Zhao, Jing Hua

AU - Albrecht, Eva

AU - Corre, Tanguy

AU - Ingelsson, Erik

AU - Hayward, Caroline

AU - Magnusson, Patrik K E

AU - Smith, Erin N

AU - Ulivi, Shelia

AU - Warrington, Nicole M

AU - Zgaga, Lina

AU - Alavere, Helen

AU - Amin, Najaf

AU - Aspelund, Thor

AU - Bandinelli, Stefania

AU - Barroso, Inês

AU - Berenson, Gerald S

AU - Bergmann, Sven

AU - Blackburn, Hannah

AU - Boerwinkle, Eric

AU - Hofman, Albert

AU - Kraft, Peter

AU - Laven, Joop S E

AU - Oostra, Ben A

AU - Rivadeneira, Fernando

AU - van Meurs, Joyce B J

AU - van Duijn, Cornelia M

AU - Uitterlinden, André G

PY - 2010/12

Y1 - 2010/12

N2 - To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 x 10(-60)) and 9q31.2 (P = 2.2 x 10(-33)), we identified 30 new menarche loci (all P < 5 x 10(-8)) and found suggestive evidence for a further 10 loci (P < 1.9 x 10(-6)). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.

AB - To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 x 10(-60)) and 9q31.2 (P = 2.2 x 10(-33)), we identified 30 new menarche loci (all P < 5 x 10(-8)) and found suggestive evidence for a further 10 loci (P < 1.9 x 10(-6)). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.

U2 - 10.1038/ng.714

DO - 10.1038/ng.714

M3 - Article

C2 - 21102462

SN - 1061-4036

VL - 42

SP - 1077

EP - 1085

JO - Nature Genetics

JF - Nature Genetics

IS - 12

ER -

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

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