Thoracic Aortic Diameter and Cardiovascular Events and Mortality among Women and Men

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Abstract

Background
Thoracic aortic diameter may have a role as a biomarker for major adverse cardiovascular events.

Purpose
To evaluate the sex-specific association of the diameters of the ascending (AA) and descending (DA) thoracic aorta with risk of stroke, coronary heart disease, heart failure, cardiovascular mortality, and all-cause mortality.

Materials and Methods
Study participants from the population-based Rotterdam Study who underwent multidetector-row CT between 2003 and 2006 were evaluated. Cox proportional hazard models were conducted to evaluate the associations of AA and DA diameters indexed and not indexed for body mass index (BMI) with cardiovascular events and mortality for men and women. Hazard ratios (HRs) were calculated per 1-unit greater SD of aortic diameters.

Results
A total of 2178 participants (mean age, 69 years; 55% women) were included. Mean follow-up was 9 years. Each 0.23-mm/(kg/m2) larger BMI-indexed AA diameter was associated with a 33% higher cardiovascular mortality risk in women (HR, 1.33; 95% CI: 1.03, 1.73). Each 0.16-mm/(kg/m2) larger BMI-indexed DA diameter was associated with a 38% higher risk of stroke (HR, 1.38; 95% CI: 1.07, 1.78) and with a 46% greater risk of cardiovascular mortality (HR, 1.46; 95% CI: 1.10, 1.94) in women. Larger BMI-indexed AA and DA diameters were associated with greater risk of all-cause mortality in both sexes.

Conclusion
Larger ascending and descending thoracic aortic diameters indexed by body mass index were associated with greater risk of adverse cardiovascular outcomes and mortality in women and men.

Clinical trial registration no. NTR6831
Original languageEnglish
Pages (from-to)208-215
Number of pages8
JournalRadiology
Volume304
Issue number1
DOIs
Publication statusPublished - 12 Apr 2022

Bibliographical note

Funding Information:
The Rotterdam Study is supported by Erasmus MC and Erasmus University, Rotterdam, the Netherlands; the Netherlands Organization for Scientific Research (NWO); the Netherlands Organization for Health Research and Development (ZonMw; grant 849200014 and VENI 91616079); the Research Institute for Diseases in the Elderly (RIDE); the Ministry of Education, Culture and Science; the Ministry for Health, Welfare and Sports; the European Commission (DG XII); and the Municipality of Rotterdam. L.R.B. supported by the Dutch Heart Foundation (2013T093).

Publisher Copyright:
© RSNA, 2022.

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