Abstract
Inherited thrombophilia is defined as a genetically determined tendency to develop venous thromboembolism. In children, inherited thrombophilia contributes to the development of pediatric thromboembolic disease. As a consequence, pediatric hematologists are increasingly requested to test thrombophilia in pediatric patients with thrombosis or asymptomatic children from thrombophilic families. This article reviews the benefits and limitations of testing for thrombophilic disorders, for example, factor V Leiden, prothrombin mutation, and deficiencies of antithrombin, protein C, or protein S in childhood.
Original language | English |
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Pages (from-to) | 794-801 |
Journal | Seminars in Thrombosis and Hemostasis |
Volume | 37 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2011 |
Externally published | Yes |