TY - JOUR
T1 - Thyroglobulin and thyroglobulin antibody
T2 - an updated clinical and laboratory expert consensus
AU - Giovanella, Luca
AU - D'Aurizio, Federica
AU - hsTg&TgAb Consensus Working Group
AU - Algeciras-Schimnich, Alicia
AU - Görges, Rainer
AU - Petranovic Ovcaricek, Petra
AU - Tuttle, R. Michael
AU - Visser, W. Edward
AU - Verburg, Frederik A.
N1 - Publisher Copyright:
© The Author(s) 2023.
PY - 2023/8
Y1 - 2023/8
N2 - OBJECTIVE: Thyroglobulin measurement is the cornerstone of modern management of differentiated thyroid cancer, with clinical decisions on treatment and follow-up based on the results of such measurements. However, numerous factors need to be considered regarding measurement with and interpretation of thyroglobulin assay results. DESIGN: The present document provides an integrated update to the 2013 and 2014 separate clinical position papers of our group on these issues. METHODS: Issues concerning analytical and clinical aspects of highly-sensitive thyroglobulin measurement will be reviewed and discussed based on an extensive analysis of the available literature. RESULTS: Thyroglobulin measurement remains a highly complex process with many pitfalls and major sources of interference, especially anti-thyroglobulin antibodies, need to be assessed, considered and, when necessary, dealt with appropriately. CONCLUSIONS: Our expert consensus group formulated 53 practical, graded recommendations for guidance on highly-sensitive thyroglobulin and TgAb in laboratory and clinical practice, especially valuable where current guidelines do not offer sufficient guidance.
AB - OBJECTIVE: Thyroglobulin measurement is the cornerstone of modern management of differentiated thyroid cancer, with clinical decisions on treatment and follow-up based on the results of such measurements. However, numerous factors need to be considered regarding measurement with and interpretation of thyroglobulin assay results. DESIGN: The present document provides an integrated update to the 2013 and 2014 separate clinical position papers of our group on these issues. METHODS: Issues concerning analytical and clinical aspects of highly-sensitive thyroglobulin measurement will be reviewed and discussed based on an extensive analysis of the available literature. RESULTS: Thyroglobulin measurement remains a highly complex process with many pitfalls and major sources of interference, especially anti-thyroglobulin antibodies, need to be assessed, considered and, when necessary, dealt with appropriately. CONCLUSIONS: Our expert consensus group formulated 53 practical, graded recommendations for guidance on highly-sensitive thyroglobulin and TgAb in laboratory and clinical practice, especially valuable where current guidelines do not offer sufficient guidance.
UR - http://www.scopus.com/inward/record.url?scp=85168715483&partnerID=8YFLogxK
U2 - 10.1093/ejendo/lvad109
DO - 10.1093/ejendo/lvad109
M3 - Article
C2 - 37625447
AN - SCOPUS:85168715483
SN - 0804-4643
VL - 189
SP - R11-R27
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
IS - 2
ER -
