Tigecycline Potentiates Clarithromycin Activity against Mycobacterium avium In Vitro

Hannelore Bax; Irma Woudenberg; Marian ten Kate; Annelies Verbon; Jurriaan de Steenwinkel

doi:10.1128/AAC.02864-15

Tigecycline Potentiates Clarithromycin Activity against Mycobacterium avium In Vitro

Hannelore Bax, Irma Woudenberg, Marian ten Kate, Annelies Verbon, Jurriaan de Steenwinkel

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

Abstract

The in vitro activities of clarithromycin and tigecycline alone and in combination against Mycobacterium avium were assessed. The activity of clarithromycin was time dependent, highly variable, and often resulted in clarithromycin resistance. Tigecycline showed concentration-dependent activity, and mycobacterial killing could only be achieved at high concentrations. Tigecycline enhanced clarithromycin activity against M. avium and prevented clarithromycin resistance. Whether there is clinical usefulness of tigecycline in the treatment of M. avium infections needs further study.

Original language	Undefined/Unknown
Pages (from-to)	2577-2579
Number of pages	3
Journal	Antimicrobial Agents & Chemotherapy
Volume	60
Issue number	4
DOIs	https://doi.org/10.1128/AAC.02864-15
Publication status	Published - 2016

Research programs

EMC MM-04-28-01
EMC MM-04-28-04

Access to Document

10.1128/AAC.02864-15

Cite this

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abstract = "The in vitro activities of clarithromycin and tigecycline alone and in combination against Mycobacterium avium were assessed. The activity of clarithromycin was time dependent, highly variable, and often resulted in clarithromycin resistance. Tigecycline showed concentration-dependent activity, and mycobacterial killing could only be achieved at high concentrations. Tigecycline enhanced clarithromycin activity against M. avium and prevented clarithromycin resistance. Whether there is clinical usefulness of tigecycline in the treatment of M. avium infections needs further study.",

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AU - Bax, Hannelore

AU - Woudenberg, Irma

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AU - Verbon, Annelies

AU - de Steenwinkel, Jurriaan

PY - 2016

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AB - The in vitro activities of clarithromycin and tigecycline alone and in combination against Mycobacterium avium were assessed. The activity of clarithromycin was time dependent, highly variable, and often resulted in clarithromycin resistance. Tigecycline showed concentration-dependent activity, and mycobacterial killing could only be achieved at high concentrations. Tigecycline enhanced clarithromycin activity against M. avium and prevented clarithromycin resistance. Whether there is clinical usefulness of tigecycline in the treatment of M. avium infections needs further study.

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DO - 10.1128/AAC.02864-15

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