Time Course of Atrial Fibrillation in Patients With Congenital Heart Defects

Christophe Teuwen, Tanwier Ramdjan, M Gotte, BJJM Brundel, R Evertz, JWJ Vriend, SG Molhoek, HGR Dorman, JM van Opstal, TC Konings, P van der Voort, E Delacretaz, Charlotte Houck, Ameeta Yaksh, LJ Jansz, Maarten Witsenburg, Jolien Roos - Hesselink, JK Triedman, Ad Bogers, Natasja de Groot

Research output: Contribution to journalArticleAcademic

59 Citations (Scopus)


Background The incidence of atrial fibrillation (AF) is rising in the aging patients with congenital heart defects (CHD). However, studies reporting on AF in patients with CHD are scarce. The aim of this multicenter study was to examine in a large cohort of patients with a variety of CHD: (1) the age of onset and initial treatment of AF, coexistence of atrial tachyarrhythmia and (2) progression of paroxysmal to (long-standing) persistent/permanent AF during long-term follow-up. Methods and Results Patients (n=199) with 15 different CHD and documented AF episodes were studied. AF developed at 4917 years. Regular atrial tachycardia (AT) coexisting with AF occurred in 65 (33%) patients; 65% initially presented with regular AT. At the end of a follow-up period of 5 (0-24) years, the ECG showed AF in 81 patients (41%). In a subgroup of 114 patients, deterioration from paroxysm of AF to (long-standing) persistent/permanent AF was observed in 29 patients (26%) after only 3 (0-18) years of the first AF episode. Cerebrovascular accidents/transient ischemic attacks occurred in 26 patients (13%), although a substantial number (n=16) occurred before the first documented AF episode. Conclusions Age at development of AF in patients with CHD is relatively young compared with the patients without CHD. Coexistence of episodes of AF and regular AT occurred in a considerable number of patients; most of them initially presented with regular AT. The fast and frequent progression from paroxysmal to (long-standing) persistent or permanent AF episodes justifies close follow-up and early, aggressive therapy of both AT and AF.
Original languageEnglish
Pages (from-to)1065-1072
Number of pages8
JournalCirculation-arrhythmia and electrophysiology
Issue number5
Publication statusPublished - 2015

Research programs

  • EMC COEUR-09


Dive into the research topics of 'Time Course of Atrial Fibrillation in Patients With Congenital Heart Defects'. Together they form a unique fingerprint.

Cite this