Time to pregnancy after a previous miscarriage in subfertile couples

T Cox, JW (Jan Willem) van der Steeg, P (Pieternel) Steures, PGA Hompes, Freddy Veen, Rene Eijkemans, JHS van Leeuwen, C Renckens, PMM Bossuyt, BWJ (Ben) Mol

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Objective: To assess the time to spontaneous ongoing pregnancy after a previous miscarriage in subfertile couples. Design: A prospective cohort study. Setting: The study was conducted in 38 fertility centers in the Netherlands. Patient(s): Subfertile couples who miscarried after completing their basic fertility work-up. Intervention(s): Expectant management after a miscarriage. Main Outcome Measure(s): Spontaneous ongoing pregnancy. Result(s): We included 5,663 subfertile couples, of which 1,098 (19%) conceived spontaneously. Among these 1,098 couples, 199 (18%) miscarried and these couples were included in the present study. Follow-up was completed for 171 couples, of which 95 conceived again within 24 months of follow-up. Of these 95 pregnancies, 86 (91%) were ongoing. The cumulative spontaneous ongoing pregnancy rate (PR) after 24 months was 70% (95% confidence interval [CI] 59%-81%). Conclusion(s): Subfertile couples, who experience a treatment-independent pregnancy resulting in a miscarriage, have very good prospects of a spontaneous ongoing pregnancy in the near future. This information is useful in counseling couples who had a miscarriage after a previous period of subfertility. (Fertil Steril(R) 2010;94:485-8. (C) 2010 by American Society for Reproductive Medicine.)
Original languageUndefined/Unknown
Pages (from-to)485-488
Number of pages4
JournalFertility & Sterility
Issue number2
Publication statusPublished - 2010

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