Tissue Preservation and Factors Affecting Tissue Quality

Peter H.J. Riegman*

*Corresponding author for this work

Research output: Chapter/Conference proceedingChapterAcademic


Acquisition of reliable and reproducible results from tissue samples can be complicated due to the introduced variations in the signals to be measured during the sample pre-analytical phase. Such variations are introduced during tissue processing because the cells in the tissue are still alive and respond to their surroundings until they are conserved for future use. In addition, tissue fixation methods can even alter the chemical structure of the signals. Standardization of the pre-analytical or pre-examination processes according to ISO Technical Standards that describe the specifications for pre-examination processes can largely avoid the introduction of different incomparable variations. Since, not all steps can be standardized, the technical standards ask for documentation of these steps. This documentation can be used as sample metadata to determine if samples are fit for purpose and comparable. Highlights on how to approach and implement such standards in a biobank is discussed in more detail in this chapter.

Original languageEnglish
Title of host publicationBiobanking of Human Biospecimens
Subtitle of host publicationLessons from 25 Years of Biobanking Experience, Second Edition
EditorsPierre Hainaut, Jim Vaught, Kurt Zatloukal, Markus Pasterk
PublisherSpringer Nature
Number of pages16
ISBN (Electronic)9783030559014
ISBN (Print)9783030559007
Publication statusPublished - 1 Jan 2021

Bibliographical note

Publisher Copyright:
© Springer Nature Switzerland AG 2017, 2021.


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