Total cerebral blood flow in relation to cognitive function: The Rotterdam Scan Study

Marielle Poels; Arfan Ikram; Meike Vernooij; Gabriel Krestin; Bert Hofman; Wiro Niessen; Aad van der Lugt; Monique Breteler

doi:10.1038/jcbfm.2008.62

Total cerebral blood flow in relation to cognitive function: The Rotterdam Scan Study

Marielle Poels, Arfan Ikram, Meike Vernooij, Gabriel Krestin, Bert Hofman, Wiro Niessen, Aad van der Lugt, Monique Breteler

Research output: Contribution to journal › Article › Academic › peer-review

70 Citations (Scopus)

Abstract

Cerebral hypoperfusion has been associated with worse cognitive function. We investigated the association between cerebral blood flow and cognition and whether this association is independent of brain volume. In 892 participants, aged 60 to 91 years, of the population-based Rotterdam Scan study, we measured total cerebral blood flow (tCBF) and brain volume using magnetic resonance imaging. Lower tCBF was associated with worse information-processing speed, executive function, and global cognition. However, after correcting tCBF for brain volume, these associations disappeared. The association between tCBF and cognition may be mediated or confounded by brain atrophy. Future studies on tCBF should take into account brain atrophy.

Original language	Undefined/Unknown
Pages (from-to)	1652-1655
Number of pages	4
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	28
Issue number	10
DOIs	https://doi.org/10.1038/jcbfm.2008.62
Publication status	Published - 2008

Access to Document

10.1038/jcbfm.2008.62

http://hdl.handle.net/1765/14792

Cite this

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title = "Total cerebral blood flow in relation to cognitive function: The Rotterdam Scan Study",

abstract = "Cerebral hypoperfusion has been associated with worse cognitive function. We investigated the association between cerebral blood flow and cognition and whether this association is independent of brain volume. In 892 participants, aged 60 to 91 years, of the population-based Rotterdam Scan study, we measured total cerebral blood flow (tCBF) and brain volume using magnetic resonance imaging. Lower tCBF was associated with worse information-processing speed, executive function, and global cognition. However, after correcting tCBF for brain volume, these associations disappeared. The association between tCBF and cognition may be mediated or confounded by brain atrophy. Future studies on tCBF should take into account brain atrophy.",

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T1 - Total cerebral blood flow in relation to cognitive function: The Rotterdam Scan Study

AU - Poels, Marielle

AU - Ikram, Arfan

AU - Vernooij, Meike

AU - Krestin, Gabriel

AU - Hofman, Bert

AU - Niessen, Wiro

AU - van der Lugt, Aad

AU - Breteler, Monique

PY - 2008

Y1 - 2008

N2 - Cerebral hypoperfusion has been associated with worse cognitive function. We investigated the association between cerebral blood flow and cognition and whether this association is independent of brain volume. In 892 participants, aged 60 to 91 years, of the population-based Rotterdam Scan study, we measured total cerebral blood flow (tCBF) and brain volume using magnetic resonance imaging. Lower tCBF was associated with worse information-processing speed, executive function, and global cognition. However, after correcting tCBF for brain volume, these associations disappeared. The association between tCBF and cognition may be mediated or confounded by brain atrophy. Future studies on tCBF should take into account brain atrophy.

AB - Cerebral hypoperfusion has been associated with worse cognitive function. We investigated the association between cerebral blood flow and cognition and whether this association is independent of brain volume. In 892 participants, aged 60 to 91 years, of the population-based Rotterdam Scan study, we measured total cerebral blood flow (tCBF) and brain volume using magnetic resonance imaging. Lower tCBF was associated with worse information-processing speed, executive function, and global cognition. However, after correcting tCBF for brain volume, these associations disappeared. The association between tCBF and cognition may be mediated or confounded by brain atrophy. Future studies on tCBF should take into account brain atrophy.

U2 - 10.1038/jcbfm.2008.62

DO - 10.1038/jcbfm.2008.62

M3 - Article

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EP - 1655

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - 10

ER -