Abstract
Original language | Undefined/Unknown |
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Pages (from-to) | 1021-1032 |
Number of pages | 12 |
Journal | Human Mutation |
Volume | 35 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2014 |
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Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats. / Ballantyne, Kaye; Ralf, Arwin; Aboukhalid, R; Achakzai, NM; Anjos, MJ; Ayub, Q; Balazic, J; Ballantyne, J; Ballard, DJ; Berger, B; Bobillo, C; Bouabdellah, M; Burri, H; Capal, T; Caratti, S; Cardenas, J; Cartault, F; Carvalho, EF; Carvalho, M; Cheng, BW; Coble, MD; Comas, D; Corach, D; D'Amato, ME; Davison, S; de Knijff, P; De Ungria, MCA; Decorte, R; Dobosz, T; Dupuy, BM; Elmrghni, S; Gliwinski, M; Gomes, SC; Grol, L; Haas, C; Hanson, E; Henke, J; Henke, L; Herrera-Rodriguez, F; Hill, CR; Holmlund, G; Honda, K; Immel, UD; Inokuchi, S; Jobling, MA; Kaddura, M; Kim, JS; Kim, SH; Kim, W; King, TE; Klausriegler, E; Kling, D; Kovacevic, L; Kovatsi, L; Krajewski, P; Kravchenko, S; Larmuseau, MHD; Lee, EY; Lessig, R; Livshits, LA; Marjanovic, D; Minarik, M; Mizuno, N; Moreira, H; Morling, N; Mukherjee, M; Munier, P; Nagaraju, J; Neuhuber, F; Nie, SJ; Nilasitsataporn, P; Nishi, T; Oh, HH; Olofsson, J; Onofri, V; Palo, JU; Pamjav, H; Parson, W; Petlach, M; Phillips, C; Ploski, R; Prasad, SPR; Primorac, D; Purnomo, GA; Purps, J; Rangel-Villalobos, H; Rebala, K; Rerkamnuaychoke, B; Gonzalez, DR; Robino, C; Roewer, L; De Rosa, A; Sajantila, A; Sala, A; Salvador, JM; Sanz, P; Schmitt, C; Sharma, AK; De Silva, DA; Shin, KJ; Sijen, T; Sirker, M; Sivakova, D; Skaro, V; Solano-Matamoros, C; Souto, L; Stenzl, V; Sudoyo, H; Syndercombe-Court, D; Tagliabracci, A; Taylor, D; Tillmar, A; Tsybovsky, IS; Tyler-Smith, C; van der Gaag, KJ; Vanek, D; Volgyi, A; Ward, D; Willemse, P; Yap, EPH; Yong, RYY; Pajnic, IZ; Kayser, Manfred.
In: Human Mutation, Vol. 35, No. 8, 2014, p. 1021-1032.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats
AU - Ballantyne, Kaye
AU - Ralf, Arwin
AU - Aboukhalid, R
AU - Achakzai, NM
AU - Anjos, MJ
AU - Ayub, Q
AU - Balazic, J
AU - Ballantyne, J
AU - Ballard, DJ
AU - Berger, B
AU - Bobillo, C
AU - Bouabdellah, M
AU - Burri, H
AU - Capal, T
AU - Caratti, S
AU - Cardenas, J
AU - Cartault, F
AU - Carvalho, EF
AU - Carvalho, M
AU - Cheng, BW
AU - Coble, MD
AU - Comas, D
AU - Corach, D
AU - D'Amato, ME
AU - Davison, S
AU - de Knijff, P
AU - De Ungria, MCA
AU - Decorte, R
AU - Dobosz, T
AU - Dupuy, BM
AU - Elmrghni, S
AU - Gliwinski, M
AU - Gomes, SC
AU - Grol, L
AU - Haas, C
AU - Hanson, E
AU - Henke, J
AU - Henke, L
AU - Herrera-Rodriguez, F
AU - Hill, CR
AU - Holmlund, G
AU - Honda, K
AU - Immel, UD
AU - Inokuchi, S
AU - Jobling, MA
AU - Kaddura, M
AU - Kim, JS
AU - Kim, SH
AU - Kim, W
AU - King, TE
AU - Klausriegler, E
AU - Kling, D
AU - Kovacevic, L
AU - Kovatsi, L
AU - Krajewski, P
AU - Kravchenko, S
AU - Larmuseau, MHD
AU - Lee, EY
AU - Lessig, R
AU - Livshits, LA
AU - Marjanovic, D
AU - Minarik, M
AU - Mizuno, N
AU - Moreira, H
AU - Morling, N
AU - Mukherjee, M
AU - Munier, P
AU - Nagaraju, J
AU - Neuhuber, F
AU - Nie, SJ
AU - Nilasitsataporn, P
AU - Nishi, T
AU - Oh, HH
AU - Olofsson, J
AU - Onofri, V
AU - Palo, JU
AU - Pamjav, H
AU - Parson, W
AU - Petlach, M
AU - Phillips, C
AU - Ploski, R
AU - Prasad, SPR
AU - Primorac, D
AU - Purnomo, GA
AU - Purps, J
AU - Rangel-Villalobos, H
AU - Rebala, K
AU - Rerkamnuaychoke, B
AU - Gonzalez, DR
AU - Robino, C
AU - Roewer, L
AU - De Rosa, A
AU - Sajantila, A
AU - Sala, A
AU - Salvador, JM
AU - Sanz, P
AU - Schmitt, C
AU - Sharma, AK
AU - De Silva, DA
AU - Shin, KJ
AU - Sijen, T
AU - Sirker, M
AU - Sivakova, D
AU - Skaro, V
AU - Solano-Matamoros, C
AU - Souto, L
AU - Stenzl, V
AU - Sudoyo, H
AU - Syndercombe-Court, D
AU - Tagliabracci, A
AU - Taylor, D
AU - Tillmar, A
AU - Tsybovsky, IS
AU - Tyler-Smith, C
AU - van der Gaag, KJ
AU - Vanek, D
AU - Volgyi, A
AU - Ward, D
AU - Willemse, P
AU - Yap, EPH
AU - Yong, RYY
AU - Pajnic, IZ
AU - Kayser, Manfred
PY - 2014
Y1 - 2014
N2 - Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836-0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father-son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RMY-STRs in identifying and separating unrelated and related males and provides a reference database. Published 2014 Wiley Periodicals, Inc.**
AB - Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836-0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father-son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RMY-STRs in identifying and separating unrelated and related males and provides a reference database. Published 2014 Wiley Periodicals, Inc.**
U2 - 10.1002/humu.22599
DO - 10.1002/humu.22599
M3 - Article
VL - 35
SP - 1021
EP - 1032
JO - Human Mutation
JF - Human Mutation
SN - 1059-7794
IS - 8
ER -