Towards standardized and clinically relevant definitions of hypoxemia and hyperoxemia in preterm infants: A systematic review

In neonatal care, maintaining oxygen levels in the target range is essential to minimize adverse outcomes. Both episodes of hyperoxemia and hypoxemia are associated with adverse neonatal outcomes. Criteria to determine the hypoxemic and hyperoxemic burden are currently not standardized or generally applied in clinical care. This results in difficulty to identify clinically relevant events in preterm infants. Clinical decisions and interventions are therefore mostly based on the experience of the clinical team. This systematic review aims to provide an overview of the used definitions for hypoxemia and hyperoxemia in preterm infants, based on continuous monitoring techniques and the relation to neonatal outcome (PROSPERO: CRD42023493201).