TY - JOUR
T1 - Towards the personalization of septic shock resuscitation
T2 - The fundamentals of ANDROMEDA-SHOCK-2 trial
AU - Ramasco, F.
AU - Aguilar, G.
AU - Aldecoa, C.
AU - Bakker, J.
AU - Carmona, P.
AU - Dominguez, D.
AU - Galiana, M.
AU - Hernández, G.
AU - Kattan, E.
AU - Olea, C.
AU - Ospina-Tascón, G.
AU - Pérez, A.
AU - Ramos, K.
AU - Ramos, S.
AU - Tamayo, G.
AU - Tuero, G.
AU - the ANDROMEDA-SHOCK-2 Spanish Investigators, Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor (SEDAR)
N1 - Publisher Copyright:
© 2023
PY - 2024/2
Y1 - 2024/2
N2 - Septic shock is a highly lethal and prevalent disease. Progressive circulatory dysfunction leads to tissue hypoperfusion and hypoxia, eventually evolving to multiorgan dysfunction and death. Prompt resuscitation may revert these pathogenic mechanisms, restoring oxygen delivery and organ function. High heterogeneity exists among the determinants of circulatory dysfunction in septic shock, and current algorithms provide a stepwise and standardized approach to conduct resuscitation. This review provides the pathophysiological and clinical rationale behind ANDROMEDA-SHOCK-2, an ongoing multicenter randomized controlled trial that aims to compare a personalized resuscitation strategy based on clinical phenotyping and peripheral perfusion assessment, versus standard of care, in early septic shock resuscitation.
AB - Septic shock is a highly lethal and prevalent disease. Progressive circulatory dysfunction leads to tissue hypoperfusion and hypoxia, eventually evolving to multiorgan dysfunction and death. Prompt resuscitation may revert these pathogenic mechanisms, restoring oxygen delivery and organ function. High heterogeneity exists among the determinants of circulatory dysfunction in septic shock, and current algorithms provide a stepwise and standardized approach to conduct resuscitation. This review provides the pathophysiological and clinical rationale behind ANDROMEDA-SHOCK-2, an ongoing multicenter randomized controlled trial that aims to compare a personalized resuscitation strategy based on clinical phenotyping and peripheral perfusion assessment, versus standard of care, in early septic shock resuscitation.
UR - http://www.scopus.com/inward/record.url?scp=85184069793&partnerID=8YFLogxK
U2 - 10.1016/j.redar.2023.07.006
DO - 10.1016/j.redar.2023.07.006
M3 - Article
AN - SCOPUS:85184069793
SN - 0034-9356
VL - 71
SP - 112
EP - 124
JO - Revista Espanola de Anestesiologia y Reanimacion
JF - Revista Espanola de Anestesiologia y Reanimacion
IS - 2
ER -