Towards the personalization of septic shock resuscitation: The fundamentals of ANDROMEDA-SHOCK-2 trial

F. Ramasco*, G. Aguilar, C. Aldecoa, J. Bakker, P. Carmona, D. Dominguez, M. Galiana, G. Hernández, E. Kattan, C. Olea, G. Ospina-Tascón, A. Pérez, K. Ramos, S. Ramos, G. Tamayo, G. Tuero, for the ANDROMEDA-SHOCK-2 Spanish Investigators, Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor (SEDAR)

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

Septic shock is a highly lethal and prevalent disease. Progressive circulatory dysfunction leads to tissue hypoperfusion and hypoxia, eventually evolving to multiorgan dysfunction and death. Prompt resuscitation may revert these pathogenic mechanisms, restoring oxygen delivery and organ function. High heterogeneity exists among the determinants of circulatory dysfunction in septic shock, and current algorithms provide a stepwise and standardized approach to conduct resuscitation. This review provides the pathophysiological and clinical rationale behind ANDROMEDA-SHOCK-2, an ongoing multicenter randomized controlled trial that aims to compare a personalized resuscitation strategy based on clinical phenotyping and peripheral perfusion assessment, versus standard of care, in early septic shock resuscitation.

Original languageEnglish
Pages (from-to)112-124
Number of pages13
JournalRevista Espanola de Anestesiologia y Reanimacion
Volume71
Issue number2
DOIs
Publication statusPublished - Feb 2024

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