TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2

S Venkatesan; M Hoogstraat; E Caljouw; T Pierson; Jochem Spoor; Lona Moradi - Zeneyedpour; Erik jan Dubbink; Lennard Dekker; Mariëlle van der Kaaij; Jenneke Kloezeman; Lotte Berghauser Pont; N J M Besselink; Theo Luider; J Joore; John Martens; Martine Lamfers; Stefan Sleijfer; Sieger Leenstra

doi:10.18632/oncotarget.11205

TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2

S Venkatesan
, M Hoogstraat
, E Caljouw
, T Pierson
, Jochem Spoor
, Lona Moradi - Zeneyedpour
, Erik jan Dubbink
, Lennard Dekker
, Mariëlle van der Kaaij
, Jenneke Kloezeman
, Lotte Berghauser Pont
, N J M Besselink
, Theo Luider
, J Joore
, John Martens
, Martine Lamfers
, Stefan Sleijfer
, Sieger Leenstra

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

46 Downloads (Pure)

Original language	Undefined/Unknown
Pages (from-to)	58435-58444
Number of pages	10
Journal	Oncotarget
Volume	7
Issue number	36
DOIs	https://doi.org/10.18632/oncotarget.11205
Publication status	Published - 2016

Research programs

EMC MM-03-24-01
EMC MM-03-44-06
EMC OR-01-45-01

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10.18632/oncotarget.11205

11205-169729-2-PB.pdfFinal published version, 4.42 MB

http://hdl.handle.net/1765/93385

Cite this

Venkatesan, S., Hoogstraat, M., Caljouw, E., Pierson, T., Spoor, J., Moradi - Zeneyedpour, L., Dubbink, E. J., Dekker, L., van der Kaaij, M., Kloezeman, J., Berghauser Pont, L., Besselink, N. J. M., Luider, T., Joore, J., Martens, J., Lamfers, M., Sleijfer, S., & Leenstra, S. (2016). TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2. Oncotarget, 7(36), 58435-58444. https://doi.org/10.18632/oncotarget.11205

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title = "TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2",

author = "S Venkatesan and M Hoogstraat and E Caljouw and T Pierson and Jochem Spoor and \{Moradi - Zeneyedpour\}, Lona and Dubbink, \{Erik jan\} and Lennard Dekker and \{van der Kaaij\}, Mari{\"e}lle and Jenneke Kloezeman and \{Berghauser Pont\}, Lotte and Besselink, \{N J M\} and Theo Luider and J Joore and John Martens and Martine Lamfers and Stefan Sleijfer and Sieger Leenstra",

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doi = "10.18632/oncotarget.11205",

language = "Undefined/Unknown",

volume = "7",

pages = "58435--58444",

journal = "Oncotarget",

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publisher = "Impact Journals LLC",

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Venkatesan, S, Hoogstraat, M, Caljouw, E, Pierson, T, Spoor, J , Moradi - Zeneyedpour, L , Dubbink, EJ, Dekker, L, van der Kaaij, M, Kloezeman, J, Berghauser Pont, L, Besselink, NJM, Luider, T, Joore, J, Martens, J , Lamfers, M , Sleijfer, S & Leenstra, S 2016, 'TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2', Oncotarget, vol. 7, no. 36, pp. 58435-58444. https://doi.org/10.18632/oncotarget.11205

TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2. / Venkatesan, S; Hoogstraat, M; Caljouw, E et al.
In: Oncotarget, Vol. 7, No. 36, 2016, p. 58435-58444.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2

AU - Venkatesan, S

AU - Hoogstraat, M

AU - Caljouw, E

AU - Pierson, T

AU - Spoor, Jochem

AU - Moradi - Zeneyedpour, Lona

AU - Dubbink, Erik jan

AU - Dekker, Lennard

AU - van der Kaaij, Mariëlle

AU - Kloezeman, Jenneke

AU - Berghauser Pont, Lotte

AU - Besselink, N J M

AU - Luider, Theo

AU - Joore, J

AU - Martens, John

AU - Lamfers, Martine

AU - Sleijfer, Stefan

AU - Leenstra, Sieger

PY - 2016

Y1 - 2016

U2 - 10.18632/oncotarget.11205

DO - 10.18632/oncotarget.11205

M3 - Article

C2 - 27533080

SN - 1949-2553

VL - 7

SP - 58435

EP - 58444

JO - Oncotarget

JF - Oncotarget

IS - 36

ER -