Tracking the ends: a dynamic protein network controls the fate of microtubule tips

Anna Akhmanova, MO Steinmetz

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811 Citations (Scopus)


Microtubule plus-end tracking proteins (+ TIPs) are a diverse group of evolutionarily conserved cellular factors that accumulate at the ends of growing microtubules. They form dynamic networks through the interaction of a limited set of protein modules, repeat sequences and linear motifs that bind to each other with moderate affinities. + TIPs regulate different aspects of cell architecture by controlling microtubule dynamics, microtubule interactions with cellular structures and signalling factors, and the forces that are exerted on microtubule networks.
Original languageUndefined/Unknown
Pages (from-to)309-322
Number of pages14
JournalNature Reviews Molecular Cell Biology
Issue number4
Publication statusPublished - 2008

Research programs

  • EMC MGC-02-13-02

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