TY - JOUR
T1 - Trajectories of subcortical volume change in schizophrenia
T2 - A 5-year follow-up
AU - van Haren, Neeltje E.M.
AU - Schnack, Hugo G.
AU - Koevoets, Martijn G.J.C.
AU - Cahn, Wiepke
AU - Hulshoff Pol, Hilleke E.
AU - Kahn, René S.
N1 - Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Longitudinal structural MRI studies in schizophrenia patients show a consistent pattern of excessive brain tissue loss over time, which appears in different stages of the disease. So far, little is known on how age (or illness duration) is related to subcortical volume change across the course of illness in schizophrenia patients as compared with healthy individuals. At baseline, 151 schizophrenia patients and 154 age and gender matched controls participated. Of these, 89 patients and 109 controlswere rescanned after an interval of approximately five years. FreeSurferwas used for subcortical segmentations. Baseline volumes and volume changes were compared. Fits with different degrees of freedomwere fitted to explain the effect of age on brain volumechange per group. These fitswere then compared between groups. At baseline, patients had significantly smaller volumes of the thalamus, and hippocampus and significantly larger volumes of the caudate, putamen, and globus pallidumas comparedwith controls. Over time, similar trajectories but with a significant difference in offset were found for caudate, amygdala, and thalamus (in males only), indicating that annual volume loss was more pronounced in patients. Curvilinear fits were found in controls for putamen and hippocampus, while linear fits were found for patients. Except for the accumbens and globus pallidum, subcortical volumes showed excessive loss over time in patients with schizophrenia. In the putamen and hippocampus, this lossmay be explained by abnormalmaturational processes during adulthood.
AB - Longitudinal structural MRI studies in schizophrenia patients show a consistent pattern of excessive brain tissue loss over time, which appears in different stages of the disease. So far, little is known on how age (or illness duration) is related to subcortical volume change across the course of illness in schizophrenia patients as compared with healthy individuals. At baseline, 151 schizophrenia patients and 154 age and gender matched controls participated. Of these, 89 patients and 109 controlswere rescanned after an interval of approximately five years. FreeSurferwas used for subcortical segmentations. Baseline volumes and volume changes were compared. Fits with different degrees of freedomwere fitted to explain the effect of age on brain volumechange per group. These fitswere then compared between groups. At baseline, patients had significantly smaller volumes of the thalamus, and hippocampus and significantly larger volumes of the caudate, putamen, and globus pallidumas comparedwith controls. Over time, similar trajectories but with a significant difference in offset were found for caudate, amygdala, and thalamus (in males only), indicating that annual volume loss was more pronounced in patients. Curvilinear fits were found in controls for putamen and hippocampus, while linear fits were found for patients. Except for the accumbens and globus pallidum, subcortical volumes showed excessive loss over time in patients with schizophrenia. In the putamen and hippocampus, this lossmay be explained by abnormalmaturational processes during adulthood.
UR - https://www.scopus.com/pages/publications/84945978680
U2 - 10.1016/j.schres.2015.09.027
DO - 10.1016/j.schres.2015.09.027
M3 - Article
C2 - 26439952
AN - SCOPUS:84945978680
SN - 0920-9964
VL - 173
SP - 140
EP - 145
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 3
ER -
