Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

P Surendran; F Drenos; R Young; H Warren; J P Cook; AK Manning; N Grarup; X Sim; D R Barnes; K Witkowska; JR Staley; V Tragante; T Tukiainen; H Yaghootkar; N Masca; DF Freitag; T Ferreira; O Giannakopoulou; A Tinker; M Harakalova; E Mihailov; Chang Liu; AT Kraja; SF Nielsen; A Rasheed; M Samue; W Zhao; LL Bonnycastle; AU Jackson; N Narisu; AJ Swift; L Southam; J Marten; J R Huyghe; A Stancakova; C Fava; T Ohlsson; A Matchan; K E Stirrups; J Bork-Jensen; AP Gjesing; J Kontto; M Perola; S Shaw-Hawkins; AS Havulinna; H Zhang; LA Donnelly; CJ Groves; NW Rayner; MJ Neville; NR Robertson; A M Yiorkas; KH Herzig; E Kajantie; W Zhang; SM Willems; L Lannfelt; G Malerba; N Soranzo; E Trabetti; N (Niek) Verweij; E Evangelou; A Moayyeri; A C Vergnaud; CP Nelson; A Poveda; TV Varga; M Caslake; AJM de Craen; S Trompet; J Luan; RA Scott; SE Harris; DCM Liewald; R Marioni; C Menni; AE Farmaki; G Hallmans; F Renstrom; JE Huffman; M Hassinen; S Burgess; RS Vasan; Janine Felix; M Uria-Nickelsen; A Malarstign; D F Reilly; Mandy van Hoek; TF Vogt; HH Lin; W Lieb; M Traylor; HS Markus; H M Highland; AE Justice; E Marouli; J Lindstrom; M Uusitupa; P Komulainen; TA Lakka; R Rauramaa; O Polasek; I Rudan; O Rolandsson; PW Franks; G Dedoussis; TD Spector; P Jousilahti; S Mannisto; IJ Deary; JM Starr; C Langenberg; NJ Wareham; MJ Brown; AF Dominiczak; JM Connell; JW Jukema; N Sattar; I Ford; CJ Packard; T Esko; R Magi; A Metspalu; RA de Boer; Paulien Meer; P van der Harst; G Gambaro; E Ingelsson; L Lind; PIW de Bakker; ME Numans; I Brandslund; C Christensen; E R B Petersen; E Korpi-Hyovalti; H Oksa; JC Chambers; JS Kooner; AIF Blakemore; S Franks; MR Jarvelin; LL Husemoen; A Linneberg; T Skaaby; B Thuesen; F Karpe; J Tuomilehto; ASF Doney; AD Morris; CNA Palmer; OL Holmen; K Hveem; CJ Willer; T Tuomi; L Groop; A Karajamaki; A Palotie; S Ripatti; V Salomaa; DS Alam; A A S Majmnder; E Di Angelantonio; R Chowdhury; MI McCarthy; N Poulter; AV Stanton; P Sever; P Amouyel; D Arveiler; S Blankenberg; J Ferrieres; F Kee; K Kuulasmaa; M Muller-Nurasyid; G Veronesi; J Virtamo; P Deloukas; P Elliott; E Zeggini; S Kathiresan; O Melander; J Kuusisto; M Laakso; S Padmanabhan; DJ Porteous; C Hayward; G Scotland; FS Collins; KL Mohlke; T Hansen; O Pedersen; M Boehnke; HM Stringham; P Frossard; C Newton-Cheh; MD Tobin; BG Nordestgaard; MJ Caulfield; A Mahajan; AP Morris; M Tomaszewski; NJ Samani; D Saleheen; FW Asselbergs; CM Lindgren; J Danesh; LV Wain; AS Butterworth; JMM Howson; PB Munroe

doi:10.1038/ng.3654

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

P Surendran, F Drenos, R Young, H Warren, J P Cook, AK Manning, N Grarup, X Sim, D R Barnes, K Witkowska, JR Staley, V Tragante, T Tukiainen, H Yaghootkar, N Masca, DF Freitag, T Ferreira, O Giannakopoulou, A Tinker, M HarakalovaE Mihailov, Chang Liu, AT Kraja, SF Nielsen, A Rasheed, M Samue, W Zhao, LL Bonnycastle, AU Jackson, N Narisu, AJ Swift, L Southam, J Marten, J R Huyghe, A Stancakova, C Fava, T Ohlsson, A Matchan, K E Stirrups, J Bork-Jensen, AP Gjesing, J Kontto, M Perola, S Shaw-Hawkins, AS Havulinna, H Zhang, LA Donnelly, CJ Groves, NW Rayner, MJ Neville, NR Robertson, A M Yiorkas, KH Herzig, E Kajantie, W Zhang, SM Willems, L Lannfelt, G Malerba, N Soranzo, E Trabetti, N (Niek) Verweij, E Evangelou, A Moayyeri, A C Vergnaud, CP Nelson, A Poveda, TV Varga, M Caslake, AJM de Craen, S Trompet, J Luan, RA Scott, SE Harris, DCM Liewald, R Marioni, C Menni, AE Farmaki, G Hallmans, F Renstrom, JE Huffman, M Hassinen, S Burgess, RS Vasan, Janine Felix, M Uria-Nickelsen, A Malarstign, D F Reilly, Mandy van Hoek, TF Vogt, HH Lin, W Lieb, M Traylor, HS Markus, H M Highland, AE Justice, E Marouli, J Lindstrom, M Uusitupa, P Komulainen, TA Lakka, R Rauramaa, O Polasek, I Rudan, O Rolandsson, PW Franks, G Dedoussis, TD Spector, P Jousilahti, S Mannisto, IJ Deary, JM Starr, C Langenberg, NJ Wareham, MJ Brown, AF Dominiczak, JM Connell, JW Jukema, N Sattar, I Ford, CJ Packard, T Esko, R Magi, A Metspalu, RA de Boer, Paulien Meer, P van der Harst, G Gambaro, E Ingelsson, L Lind, PIW de Bakker, ME Numans, I Brandslund, C Christensen, E R B Petersen, E Korpi-Hyovalti, H Oksa, JC Chambers, JS Kooner, AIF Blakemore, S Franks, MR Jarvelin, LL Husemoen, A Linneberg, T Skaaby, B Thuesen, F Karpe, J Tuomilehto, ASF Doney, AD Morris, CNA Palmer, OL Holmen, K Hveem, CJ Willer, T Tuomi, L Groop, A Karajamaki, A Palotie, S Ripatti, V Salomaa, DS Alam, A A S Majmnder, E Di Angelantonio, R Chowdhury, MI McCarthy, N Poulter, AV Stanton, P Sever, P Amouyel, D Arveiler, S Blankenberg, J Ferrieres, F Kee, K Kuulasmaa, M Muller-Nurasyid, G Veronesi, J Virtamo, P Deloukas, P Elliott, E Zeggini, S Kathiresan, O Melander, J Kuusisto, M Laakso, S Padmanabhan, DJ Porteous, C Hayward, G Scotland, FS Collins, KL Mohlke, T Hansen, O Pedersen, M Boehnke, HM Stringham, P Frossard, C Newton-Cheh, MD Tobin, BG Nordestgaard, MJ Caulfield, A Mahajan, AP Morris, M Tomaszewski, NJ Samani, D Saleheen, FW Asselbergs, CM Lindgren, J Danesh, LV Wain, AS Butterworth, JMM Howson, PB Munroe

Research output: Contribution to journal › Article › Academic › peer-review

184 Citations (Scopus)

Original language	Undefined/Unknown
Pages (from-to)	1151-1161
Number of pages	11
Journal	Nature Genetics
Volume	48
Issue number	10
DOIs	https://doi.org/10.1038/ng.3654
Publication status	Published - 2016

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10.1038/ng.3654

Cite this

Surendran, P., Drenos, F., Young, R., Warren, H., Cook, J. P., Manning, AK., Grarup, N., Sim, X., Barnes, D. R., Witkowska, K., Staley, JR., Tragante, V., Tukiainen, T., Yaghootkar, H., Masca, N., Freitag, DF., Ferreira, T., Giannakopoulou, O., Tinker, A., ... Munroe, PB. (2016). Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nature Genetics, 48(10), 1151-1161. https://doi.org/10.1038/ng.3654

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year = "2016",

doi = "10.1038/ng.3654",

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volume = "48",

pages = "1151--1161",

journal = "Nature Genetics",

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Surendran, P, Drenos, F, Young, R, Warren, H, Cook, JP, Manning, AK, Grarup, N, Sim, X, Barnes, DR, Witkowska, K, Staley, JR, Tragante, V, Tukiainen, T, Yaghootkar, H, Masca, N, Freitag, DF, Ferreira, T, Giannakopoulou, O, Tinker, A, Harakalova, M, Mihailov, E, Liu, C, Kraja, AT, Nielsen, SF, Rasheed, A, Samue, M, Zhao, W, Bonnycastle, LL, Jackson, AU, Narisu, N, Swift, AJ, Southam, L, Marten, J, Huyghe, JR, Stancakova, A, Fava, C, Ohlsson, T, Matchan, A, Stirrups, KE, Bork-Jensen, J, Gjesing, AP, Kontto, J, Perola, M, Shaw-Hawkins, S, Havulinna, AS, Zhang, H, Donnelly, LA, Groves, CJ, Rayner, NW, Neville, MJ, Robertson, NR, Yiorkas, AM, Herzig, KH, Kajantie, E, Zhang, W, Willems, SM, Lannfelt, L, Malerba, G, Soranzo, N, Trabetti, E, Verweij, N, Evangelou, E, Moayyeri, A, Vergnaud, AC, Nelson, CP, Poveda, A, Varga, TV, Caslake, M, de Craen, AJM, Trompet, S, Luan, J, Scott, RA, Harris, SE, Liewald, DCM, Marioni, R, Menni, C, Farmaki, AE, Hallmans, G, Renstrom, F, Huffman, JE, Hassinen, M, Burgess, S, Vasan, RS, Felix, J, Uria-Nickelsen, M, Malarstign, A, Reilly, DF, van Hoek, M, Vogt, TF, Lin, HH, Lieb, W, Traylor, M, Markus, HS, Highland, HM, Justice, AE, Marouli, E, Lindstrom, J, Uusitupa, M, Komulainen, P, Lakka, TA, Rauramaa, R, Polasek, O, Rudan, I, Rolandsson, O, Franks, PW, Dedoussis, G, Spector, TD, Jousilahti, P, Mannisto, S, Deary, IJ, Starr, JM, Langenberg, C, Wareham, NJ, Brown, MJ, Dominiczak, AF, Connell, JM, Jukema, JW, Sattar, N, Ford, I, Packard, CJ, Esko, T, Magi, R, Metspalu, A, de Boer, RA, Meer, P, van der Harst, P, Gambaro, G, Ingelsson, E, Lind, L, de Bakker, PIW, Numans, ME, Brandslund, I, Christensen, C, Petersen, ERB, Korpi-Hyovalti, E, Oksa, H, Chambers, JC, Kooner, JS, Blakemore, AIF, Franks, S, Jarvelin, MR, Husemoen, LL, Linneberg, A, Skaaby, T, Thuesen, B, Karpe, F, Tuomilehto, J, Doney, ASF, Morris, AD, Palmer, CNA, Holmen, OL, Hveem, K, Willer, CJ, Tuomi, T, Groop, L, Karajamaki, A, Palotie, A, Ripatti, S, Salomaa, V, Alam, DS, Majmnder, AAS, Di Angelantonio, E, Chowdhury, R, McCarthy, MI, Poulter, N, Stanton, AV, Sever, P, Amouyel, P, Arveiler, D, Blankenberg, S, Ferrieres, J, Kee, F, Kuulasmaa, K, Muller-Nurasyid, M, Veronesi, G, Virtamo, J, Deloukas, P, Elliott, P, Zeggini, E, Kathiresan, S, Melander, O, Kuusisto, J, Laakso, M, Padmanabhan, S, Porteous, DJ, Hayward, C, Scotland, G, Collins, FS, Mohlke, KL, Hansen, T, Pedersen, O, Boehnke, M, Stringham, HM, Frossard, P, Newton-Cheh, C, Tobin, MD, Nordestgaard, BG, Caulfield, MJ, Mahajan, A, Morris, AP, Tomaszewski, M, Samani, NJ, Saleheen, D, Asselbergs, FW, Lindgren, CM, Danesh, J, Wain, LV, Butterworth, AS, Howson, JMM & Munroe, PB 2016, 'Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension', Nature Genetics, vol. 48, no. 10, pp. 1151-1161. https://doi.org/10.1038/ng.3654

TY - JOUR

T1 - Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

AU - Surendran, P

AU - Drenos, F

AU - Young, R

AU - Warren, H

AU - Cook, J P

AU - Manning, AK

AU - Grarup, N

AU - Sim, X

AU - Barnes, D R

AU - Witkowska, K

AU - Staley, JR

AU - Tragante, V

AU - Tukiainen, T

AU - Yaghootkar, H

AU - Masca, N

AU - Freitag, DF

AU - Ferreira, T

AU - Giannakopoulou, O

AU - Tinker, A

AU - Harakalova, M

AU - Mihailov, E

AU - Liu, Chang

AU - Kraja, AT

AU - Nielsen, SF

AU - Rasheed, A

AU - Samue, M

AU - Zhao, W

AU - Bonnycastle, LL

AU - Jackson, AU

AU - Narisu, N

AU - Swift, AJ

AU - Southam, L

AU - Marten, J

AU - Huyghe, J R

AU - Stancakova, A

AU - Fava, C

AU - Ohlsson, T

AU - Matchan, A

AU - Stirrups, K E

AU - Bork-Jensen, J

AU - Gjesing, AP

AU - Kontto, J

AU - Perola, M

AU - Shaw-Hawkins, S

AU - Havulinna, AS

AU - Zhang, H

AU - Donnelly, LA

AU - Groves, CJ

AU - Rayner, NW

AU - Neville, MJ

AU - Robertson, NR

AU - Yiorkas, A M

AU - Herzig, KH

AU - Kajantie, E

AU - Zhang, W

AU - Willems, SM

AU - Lannfelt, L

AU - Malerba, G

AU - Soranzo, N

AU - Trabetti, E

AU - Verweij, N (Niek)

AU - Evangelou, E

AU - Moayyeri, A

AU - Vergnaud, A C

AU - Nelson, CP

AU - Poveda, A

AU - Varga, TV

AU - Caslake, M

AU - de Craen, AJM

AU - Trompet, S

AU - Luan, J

AU - Scott, RA

AU - Harris, SE

AU - Liewald, DCM

AU - Marioni, R

AU - Menni, C

AU - Farmaki, AE

AU - Hallmans, G

AU - Renstrom, F

AU - Huffman, JE

AU - Hassinen, M

AU - Burgess, S

AU - Vasan, RS

AU - Felix, Janine

AU - Uria-Nickelsen, M

AU - Malarstign, A

AU - Reilly, D F

AU - van Hoek, Mandy

AU - Vogt, TF

AU - Lin, HH

AU - Lieb, W

AU - Traylor, M

AU - Markus, HS

AU - Highland, H M

AU - Justice, AE

AU - Marouli, E

AU - Lindstrom, J

AU - Uusitupa, M

AU - Komulainen, P

AU - Lakka, TA

AU - Rauramaa, R

AU - Polasek, O

AU - Rudan, I

AU - Rolandsson, O

AU - Franks, PW

AU - Dedoussis, G

AU - Spector, TD

AU - Jousilahti, P

AU - Mannisto, S

AU - Deary, IJ

AU - Starr, JM

AU - Langenberg, C

AU - Wareham, NJ

AU - Brown, MJ

AU - Dominiczak, AF

AU - Connell, JM

AU - Jukema, JW

AU - Sattar, N

AU - Ford, I

AU - Packard, CJ

AU - Esko, T

AU - Magi, R

AU - Metspalu, A

AU - de Boer, RA

AU - Meer, Paulien

AU - van der Harst, P

AU - Gambaro, G

AU - Ingelsson, E

AU - Lind, L

AU - de Bakker, PIW

AU - Numans, ME

AU - Brandslund, I

AU - Christensen, C

AU - Petersen, E R B

AU - Korpi-Hyovalti, E

AU - Oksa, H

AU - Chambers, JC

AU - Kooner, JS

AU - Blakemore, AIF

AU - Franks, S

AU - Jarvelin, MR

AU - Husemoen, LL

AU - Linneberg, A

AU - Skaaby, T

AU - Thuesen, B

AU - Karpe, F

AU - Tuomilehto, J

AU - Doney, ASF

AU - Morris, AD

AU - Palmer, CNA

AU - Holmen, OL

AU - Hveem, K

AU - Willer, CJ

AU - Tuomi, T

AU - Groop, L

AU - Karajamaki, A

AU - Palotie, A

AU - Ripatti, S

AU - Salomaa, V

AU - Alam, DS

AU - Majmnder, A A S

AU - Di Angelantonio, E

AU - Chowdhury, R

AU - McCarthy, MI

AU - Poulter, N

AU - Stanton, AV

AU - Sever, P

AU - Amouyel, P

AU - Arveiler, D

AU - Blankenberg, S

AU - Ferrieres, J

AU - Kee, F

AU - Kuulasmaa, K

AU - Muller-Nurasyid, M

AU - Veronesi, G

AU - Virtamo, J

AU - Deloukas, P

AU - Elliott, P

AU - Zeggini, E

AU - Kathiresan, S

AU - Melander, O

AU - Kuusisto, J

AU - Laakso, M

AU - Padmanabhan, S

AU - Porteous, DJ

AU - Hayward, C

AU - Scotland, G

AU - Collins, FS

AU - Mohlke, KL

AU - Hansen, T

AU - Pedersen, O

AU - Boehnke, M

AU - Stringham, HM

AU - Frossard, P

AU - Newton-Cheh, C

AU - Tobin, MD

AU - Nordestgaard, BG

AU - Caulfield, MJ

AU - Mahajan, A

AU - Morris, AP

AU - Tomaszewski, M

AU - Samani, NJ

AU - Saleheen, D

AU - Asselbergs, FW

AU - Lindgren, CM

AU - Danesh, J

AU - Wain, LV

AU - Butterworth, AS

AU - Howson, JMM

AU - Munroe, PB

PY - 2016

Y1 - 2016

U2 - 10.1038/ng.3654

DO - 10.1038/ng.3654

M3 - Article

SN - 1061-4036

VL - 48

SP - 1151

EP - 1161

JO - Nature Genetics

JF - Nature Genetics

IS - 10

ER -