Transcription-Independent Function of Polycomb Group Protein PSC in Cell Cycle Control

A Mohd-Sarip, Anna Lagarou, CM Doyen, Jan Knaap, Ulku Aslan, Karel Bezstarosti, Y Yassin, HW Brock, Jeroen Demmers, Peter Verrijzer

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Abstract

Polycomb group (PcG) proteins control development and cell proliferation through chromatin-mediated transcriptional repression. We describe a transcription-independent function for PcG protein Posterior sex combs (PSC) in regulating the destruction of cyclin B (CYC-B). A substantial portion of PSC was found outside canonical PcG complexes, instead associated with CYC-B and the anaphase-promoting complex (APC). Cell-based experiments and reconstituted reactions established that PSC and Lemming (LMG, also called APC11) associate and ubiquitylate CYC-B cooperatively, marking it for proteosomal degradation. Thus, PSC appears to mediate both developmental gene silencing and posttranslational control of mitosis. Direct regulation of cell cycle progression might be a crucial part of the PcG system's function in development and cancer.
Original languageUndefined/Unknown
Pages (from-to)744-747
Number of pages4
JournalScience
Volume336
Issue number6082
DOIs
Publication statusPublished - 2012

Research programs

  • EMC MGC-02-21-01

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