Transcription regulation by distal enhancers: Who's in the loop?

Ralph Stadhouders, Anita van den Heuvel, Petros Kolovos, Ruud Jorna, Kris Leslie, Frank Grosveld, Eric Soler*

*Corresponding author for this work

Research output: Contribution to journalReview articlePopular

37 Citations (Scopus)


Genome-wide chromatin profiling efforts have shown that enhancers are often located at large distances from gene promoters within the noncoding genome. Whereas enhancers can stimulate transcription initiation by communicating with promoters via chromatin looping mechanisms, we propose that enhancers may also stimulate transcription elongation by physical interactions with intronic elements. We review here recent findings derived from the study of the hematopoietic system.

Original languageEnglish
Issue number4
Publication statusPublished - 2012

Bibliographical note

Funding Information:
We are thankful to the members of the F.G. laboratory for helpful comments and discussions. E.S. is supported by grants from the Netherlands Genomics Initiative (Horizon breakthrough) and the Dutch Cancer Genomics Center.


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