Transcription regulation by distal enhancers: Who's in the loop?

Ralph Stadhouders; Anita van den Heuvel; Petros Kolovos; Ruud Jorna; Kris Leslie; Frank Grosveld; Eric Soler

doi:10.4161/trns.20720

Transcription regulation by distal enhancers: Who's in the loop?

Ralph Stadhouders, Anita van den Heuvel, Petros Kolovos, Ruud Jorna, Kris Leslie, Frank Grosveld, Eric Soler^*

^*Corresponding author for this work

Cell biology

Research output: Contribution to journal › Review article › Popular

34 Citations (Scopus)

Abstract

Genome-wide chromatin profiling efforts have shown that enhancers are often located at large distances from gene promoters within the noncoding genome. Whereas enhancers can stimulate transcription initiation by communicating with promoters via chromatin looping mechanisms, we propose that enhancers may also stimulate transcription elongation by physical interactions with intronic elements. We review here recent findings derived from the study of the hematopoietic system.

Original language	English
Journal	Transcription
Volume	3
Issue number	4
DOIs	https://doi.org/10.4161/trns.20720
Publication status	Published - 2012

Bibliographical note

Funding Information:
We are thankful to the members of the F.G. laboratory for helpful comments and discussions. E.S. is supported by grants from the Netherlands Genomics Initiative (Horizon breakthrough) and the Dutch Cancer Genomics Center.

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10.4161/trns.20720

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title = "Transcription regulation by distal enhancers: Who's in the loop?",

abstract = "Genome-wide chromatin profiling efforts have shown that enhancers are often located at large distances from gene promoters within the noncoding genome. Whereas enhancers can stimulate transcription initiation by communicating with promoters via chromatin looping mechanisms, we propose that enhancers may also stimulate transcription elongation by physical interactions with intronic elements. We review here recent findings derived from the study of the hematopoietic system.",

author = "Ralph Stadhouders and {van den Heuvel}, Anita and Petros Kolovos and Ruud Jorna and Kris Leslie and Frank Grosveld and Eric Soler",

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T2 - Who's in the loop?

AU - Stadhouders, Ralph

AU - van den Heuvel, Anita

AU - Kolovos, Petros

AU - Jorna, Ruud

AU - Leslie, Kris

AU - Grosveld, Frank

AU - Soler, Eric

N1 - Funding Information: We are thankful to the members of the F.G. laboratory for helpful comments and discussions. E.S. is supported by grants from the Netherlands Genomics Initiative (Horizon breakthrough) and the Dutch Cancer Genomics Center.

PY - 2012

Y1 - 2012

N2 - Genome-wide chromatin profiling efforts have shown that enhancers are often located at large distances from gene promoters within the noncoding genome. Whereas enhancers can stimulate transcription initiation by communicating with promoters via chromatin looping mechanisms, we propose that enhancers may also stimulate transcription elongation by physical interactions with intronic elements. We review here recent findings derived from the study of the hematopoietic system.

AB - Genome-wide chromatin profiling efforts have shown that enhancers are often located at large distances from gene promoters within the noncoding genome. Whereas enhancers can stimulate transcription initiation by communicating with promoters via chromatin looping mechanisms, we propose that enhancers may also stimulate transcription elongation by physical interactions with intronic elements. We review here recent findings derived from the study of the hematopoietic system.

UR - http://www.scopus.com/inward/record.url?scp=84864081597&partnerID=8YFLogxK

U2 - 10.4161/trns.20720

DO - 10.4161/trns.20720

M3 - Review article

C2 - 22771987

AN - SCOPUS:84864081597

SN - 2154-1264

VL - 3

JO - Transcription

JF - Transcription

IS - 4

ER -

Transcription regulation by distal enhancers: Who's in the loop?

Abstract

Bibliographical note

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