Transcriptional Regulation by (Super)Enhancers: From Discovery to Mechanisms

Frank Grosveld, Jente Van Staalduinen, Ralph Stadhouders

Research output: Contribution to journalReview articleAcademicpeer-review

11 Citations (Scopus)

Abstract

Accurate control of gene expression in the right cell at the right moment is of fundamental importance to animal development and homeostasis. At the heart of gene regulation lie the enhancers, a class of gene regulatory elements that ensures precise spatiotemporal activation of gene transcription. Mammalian genomes are littered with enhancers, which are frequently organized in cooperative clusters such as locus control regions and superenhancers. Here, we discuss our current knowledge of enhancer biology, including an overview of the discovery of the various enhancer subsets and the mechanistic models used to explain their gene regulatory function.

Original languageEnglish
Pages (from-to)127-146
Number of pages20
JournalAnnual Review of Genomics and Human Genetics
Volume22
Early online date5 May 2021
DOIs
Publication statusPublished - Aug 2021

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