TY - UNPB
T1 - Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium
AU - van Velzen, Laura S
AU - Colic, Lejla
AU - Ceja, Zuriel
AU - ENIGMA Suicidal Thoughts and Behaviours Consortium
AU - Dauvermann, Maria R
AU - Villa, Luca M
AU - Savage, Hannah S
AU - Toenders, Yara J
AU - Dehestani, Niousha
AU - Zhu, Alyssa H
AU - Campos, Adrian I
AU - Salminen, Lauren E
AU - Agartz, Ingrid
AU - Alexander, Nina
AU - Ayesa-Arriola, Rosa
AU - Ballard, Elizabeth D
AU - Banaj, Nerisa
AU - Barkhau, Carlotta
AU - Başgöze, Zeynep
AU - Bauer, Jochen
AU - Benedetti, Francesco
AU - Berger, Klaus
AU - Besteher, Bianca
AU - Brosch, Katharina
AU - Canal-Rivero, Manuel
AU - Cervenka, Simon
AU - Colle, Romain
AU - Connolly, Colm G
AU - Corruble, Emmanuelle
AU - Courtet, Philippe
AU - Couvy-Duchesne, Baptiste
AU - Crespo-Facorro, Benedicto
AU - Cullen, Kathryn R
AU - Dannlowski, Udo
AU - Deverdun, Jeremy
AU - Diaz-Zuluaga, Ana M
AU - Dietze, Lorielle M F
AU - Evans, Jennifer W
AU - Fani, Negar
AU - Flinkenflügel, Kira
AU - Friedman, Naomi P
AU - Gotlib, Ian H
AU - Groenewold, Nynke A
AU - Grotegerd, Dominik
AU - Hajek, Tomas
AU - Hatoum, Alexander S
AU - Hermesdorf, Marco
AU - Hickie, Ian B
AU - Hirano, Yoshiyuki
AU - Ho, Tiffany C
AU - Li, Meng
PY - 2024/11/7
Y1 - 2024/11/7
N2 - Previous studies have suggested that alterations in white matter (WM) microstructure are implicated in suicidal thoughts and behaviours (STBs). However, findings of diffusion tensor imaging (DTI) studies have been inconsistent. In this large-scale mega-analysis conducted by the ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium, we examined WM alterations associated with STBs. Data processing was standardised across sites, and resulting WM microstructure measures (fractional anisotropy, axial diffusivity, mean diffusivity and radial diffusivity) for 25 WM tracts were pooled across 40 cohorts. We compared these measures among individuals with a psychiatric diagnosis and lifetime history of suicide attempt (
n=652; mean age=35.4±14.7; female=71.8%), individuals with a psychiatric diagnosis but no STB (i.e., clinical controls;
n=1871; mean age=34±14.8; female=59.8%), and individuals with no mental disorder diagnosis and no STB (i.e., healthy controls;
n=642; mean age=29.6±13.1; female=62.9%). We also compared these measures among individuals with recent suicidal ideation (
n=714; mean age=36.3±15.3; female=66.1%), clinical controls (
n=1184; mean age=36.8±15.6; female=63.1%), and healthy controls (
n=1240; mean age= 31.6±15.5; female=61.0%). We found subtle but statistically significant effects, such as lower fractional anisotropy associated with a history of suicide attempt, over and above the effect of psychiatric diagnoses. These effects were strongest in the corona radiata, thalamic radiation, fornix/stria terminalis, corpus callosum and superior longitudinal fasciculus. Effect sizes were small (Cohen's
d < 0.25). Recent suicidal ideation was not associated with alterations in WM microstructure. This large-scale coordinated mega-analysis revealed subtle regional and global alterations in WM microstructure in individuals with a history of suicide attempt. Longitudinal studies are needed to confirm whether these alterations are a risk factor for suicidal behaviour.
AB - Previous studies have suggested that alterations in white matter (WM) microstructure are implicated in suicidal thoughts and behaviours (STBs). However, findings of diffusion tensor imaging (DTI) studies have been inconsistent. In this large-scale mega-analysis conducted by the ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium, we examined WM alterations associated with STBs. Data processing was standardised across sites, and resulting WM microstructure measures (fractional anisotropy, axial diffusivity, mean diffusivity and radial diffusivity) for 25 WM tracts were pooled across 40 cohorts. We compared these measures among individuals with a psychiatric diagnosis and lifetime history of suicide attempt (
n=652; mean age=35.4±14.7; female=71.8%), individuals with a psychiatric diagnosis but no STB (i.e., clinical controls;
n=1871; mean age=34±14.8; female=59.8%), and individuals with no mental disorder diagnosis and no STB (i.e., healthy controls;
n=642; mean age=29.6±13.1; female=62.9%). We also compared these measures among individuals with recent suicidal ideation (
n=714; mean age=36.3±15.3; female=66.1%), clinical controls (
n=1184; mean age=36.8±15.6; female=63.1%), and healthy controls (
n=1240; mean age= 31.6±15.5; female=61.0%). We found subtle but statistically significant effects, such as lower fractional anisotropy associated with a history of suicide attempt, over and above the effect of psychiatric diagnoses. These effects were strongest in the corona radiata, thalamic radiation, fornix/stria terminalis, corpus callosum and superior longitudinal fasciculus. Effect sizes were small (Cohen's
d < 0.25). Recent suicidal ideation was not associated with alterations in WM microstructure. This large-scale coordinated mega-analysis revealed subtle regional and global alterations in WM microstructure in individuals with a history of suicide attempt. Longitudinal studies are needed to confirm whether these alterations are a risk factor for suicidal behaviour.
U2 - 10.1101/2024.11.07.24316876
DO - 10.1101/2024.11.07.24316876
M3 - Preprint
C2 - 39802789
BT - Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium
ER -
