Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome

Anne Vrieze; Els Van Nood; Frits Holleman; Jarkko Salojärvi; Ruud S Kootte; Joep F W M Bartelsman; Geesje M Dallinga-Thie; Mariette T Ackermans; Mireille J Serlie; Raish Oozeer; Muriel Derrien; Anne Druesne; Johan E T Van Hylckama Vlieg; Vincent W Bloks; Albert K Groen; Hans G H J Heilig; Erwin G Zoetendal; Erik S Stroes; Willem M de Vos; Joost B L Hoekstra; Max Nieuwdorp

doi:10.1053/j.gastro.2012.06.031

Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome

Anne Vrieze
, Els Van Nood
, Frits Holleman
, Jarkko Salojärvi
, Ruud S Kootte
, Joep F W M Bartelsman
, Geesje M Dallinga-Thie
, Mariette T Ackermans
, Mireille J Serlie
, Raish Oozeer
, Muriel Derrien
, Anne Druesne
, Johan E T Van Hylckama Vlieg
, Vincent W Bloks
, Albert K Groen
, Hans G H J Heilig
, Erwin G Zoetendal
, Erik S Stroes
, Willem M de Vos
, Joost B L Hoekstra

Max Nieuwdorp^*

^*Corresponding author for this work

Academic Medical Center

Research output: Contribution to journal › Article › Academic › peer-review

2654 Citations (Scopus)

Abstract

Alterations in intestinal microbiota are associated with obesity and insulin resistance. We studied the effects of infusing intestinal microbiota from lean donors to male recipients with metabolic syndrome on the recipients' microbiota composition and glucose metabolism. Subjects were assigned randomly to groups that were given small intestinal infusions of allogenic or autologous microbiota. Six weeks after infusion of microbiota from lean donors, insulin sensitivity of recipients increased (median rate of glucose disappearance changed from 26.2 to 45.3 μmol/kg/min; P < .05) along with levels of butyrate-producing intestinal microbiota. Intestinal microbiota might be developed as therapeutic agents to increase insulin sensitivity in humans; www.trialregister.nl; registered at the Dutch Trial Register (NTR1776).

Original language	English
Pages (from-to)	913-6.e7
Journal	Gastroenterology
Volume	143
Issue number	4
DOIs	https://doi.org/10.1053/j.gastro.2012.06.031
Publication status	Published - 1 Oct 2012
Externally published	Yes

Bibliographical note

Funding
Supported by an NWO-VENI grant 2008 (016.096.044 to M.N.),
Netherlands Foundation for Cardiovascular Excellence (2008-5 to
A.V.), an NWO-ZONMW VEMI grant (170881001 to E.v.N.), and an
NWO-Spinoza grant 2008 (W.M.d.V.).

Copyright © 2012 AGA Institute. Published by Elsevier Inc. All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1053/j.gastro.2012.06.031

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Vrieze, A., Van Nood, E., Holleman, F., Salojärvi, J., Kootte, R. S., Bartelsman, J. F. W. M., Dallinga-Thie, G. M., Ackermans, M. T., Serlie, M. J., Oozeer, R., Derrien, M., Druesne, A., Van Hylckama Vlieg, J. E. T., Bloks, V. W., Groen, A. K., Heilig, H. G. H. J., Zoetendal, E. G., Stroes, E. S., de Vos, W. M., ... Nieuwdorp, M. (2012). Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology, 143(4), 913-6.e7. https://doi.org/10.1053/j.gastro.2012.06.031

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title = "Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome",

abstract = "Alterations in intestinal microbiota are associated with obesity and insulin resistance. We studied the effects of infusing intestinal microbiota from lean donors to male recipients with metabolic syndrome on the recipients' microbiota composition and glucose metabolism. Subjects were assigned randomly to groups that were given small intestinal infusions of allogenic or autologous microbiota. Six weeks after infusion of microbiota from lean donors, insulin sensitivity of recipients increased (median rate of glucose disappearance changed from 26.2 to 45.3 μmol/kg/min; P < .05) along with levels of butyrate-producing intestinal microbiota. Intestinal microbiota might be developed as therapeutic agents to increase insulin sensitivity in humans; www.trialregister.nl; registered at the Dutch Trial Register (NTR1776).",

author = "Anne Vrieze and \{Van Nood\}, Els and Frits Holleman and Jarkko Saloj{\"a}rvi and Kootte, \{Ruud S\} and Bartelsman, \{Joep F W M\} and Dallinga-Thie, \{Geesje M\} and Ackermans, \{Mariette T\} and Serlie, \{Mireille J\} and Raish Oozeer and Muriel Derrien and Anne Druesne and \{Van Hylckama Vlieg\}, \{Johan E T\} and Bloks, \{Vincent W\} and Groen, \{Albert K\} and Heilig, \{Hans G H J\} and Zoetendal, \{Erwin G\} and Stroes, \{Erik S\} and \{de Vos\}, \{Willem M\} and Hoekstra, \{Joost B L\} and Max Nieuwdorp",

note = "Funding Supported by an NWO-VENI grant 2008 (016.096.044 to M.N.), Netherlands Foundation for Cardiovascular Excellence (2008-5 to A.V.), an NWO-ZONMW VEMI grant (170881001 to E.v.N.), and an NWO-Spinoza grant 2008 (W.M.d.V.). Copyright {\textcopyright} 2012 AGA Institute. Published by Elsevier Inc. All rights reserved.",

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doi = "10.1053/j.gastro.2012.06.031",

language = "English",

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Vrieze, A, Van Nood, E, Holleman, F, Salojärvi, J, Kootte, RS, Bartelsman, JFWM, Dallinga-Thie, GM, Ackermans, MT, Serlie, MJ, Oozeer, R, Derrien, M, Druesne, A, Van Hylckama Vlieg, JET, Bloks, VW, Groen, AK, Heilig, HGHJ, Zoetendal, EG, Stroes, ES, de Vos, WM, Hoekstra, JBL & Nieuwdorp, M 2012, 'Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome', Gastroenterology, vol. 143, no. 4, pp. 913-6.e7. https://doi.org/10.1053/j.gastro.2012.06.031

TY - JOUR

T1 - Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome

AU - Vrieze, Anne

AU - Van Nood, Els

AU - Holleman, Frits

AU - Salojärvi, Jarkko

AU - Kootte, Ruud S

AU - Bartelsman, Joep F W M

AU - Dallinga-Thie, Geesje M

AU - Ackermans, Mariette T

AU - Serlie, Mireille J

AU - Oozeer, Raish

AU - Derrien, Muriel

AU - Druesne, Anne

AU - Van Hylckama Vlieg, Johan E T

AU - Bloks, Vincent W

AU - Groen, Albert K

AU - Heilig, Hans G H J

AU - Zoetendal, Erwin G

AU - Stroes, Erik S

AU - de Vos, Willem M

AU - Hoekstra, Joost B L

AU - Nieuwdorp, Max

N1 - Funding Supported by an NWO-VENI grant 2008 (016.096.044 to M.N.), Netherlands Foundation for Cardiovascular Excellence (2008-5 to A.V.), an NWO-ZONMW VEMI grant (170881001 to E.v.N.), and an NWO-Spinoza grant 2008 (W.M.d.V.). Copyright © 2012 AGA Institute. Published by Elsevier Inc. All rights reserved.

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Alterations in intestinal microbiota are associated with obesity and insulin resistance. We studied the effects of infusing intestinal microbiota from lean donors to male recipients with metabolic syndrome on the recipients' microbiota composition and glucose metabolism. Subjects were assigned randomly to groups that were given small intestinal infusions of allogenic or autologous microbiota. Six weeks after infusion of microbiota from lean donors, insulin sensitivity of recipients increased (median rate of glucose disappearance changed from 26.2 to 45.3 μmol/kg/min; P < .05) along with levels of butyrate-producing intestinal microbiota. Intestinal microbiota might be developed as therapeutic agents to increase insulin sensitivity in humans; www.trialregister.nl; registered at the Dutch Trial Register (NTR1776).

AB - Alterations in intestinal microbiota are associated with obesity and insulin resistance. We studied the effects of infusing intestinal microbiota from lean donors to male recipients with metabolic syndrome on the recipients' microbiota composition and glucose metabolism. Subjects were assigned randomly to groups that were given small intestinal infusions of allogenic or autologous microbiota. Six weeks after infusion of microbiota from lean donors, insulin sensitivity of recipients increased (median rate of glucose disappearance changed from 26.2 to 45.3 μmol/kg/min; P < .05) along with levels of butyrate-producing intestinal microbiota. Intestinal microbiota might be developed as therapeutic agents to increase insulin sensitivity in humans; www.trialregister.nl; registered at the Dutch Trial Register (NTR1776).

U2 - 10.1053/j.gastro.2012.06.031

DO - 10.1053/j.gastro.2012.06.031

M3 - Article

C2 - 22728514

SN - 0016-5085

VL - 143

SP - 913-6.e7

JO - Gastroenterology

JF - Gastroenterology

IS - 4

ER -

Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome

Abstract

Bibliographical note

UN SDGs

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