Transforming growth factor β production during rat cytomegalovirus infection

Bart L. Haagmans; Katja J. Teerds; Adriana J.M. Van Den Eijnden-Van Raaij; Marian C. Horzinek; Virgil E.C.J. Schijns

doi:10.1099/0022-1317-78-1-205

Transforming growth factor β production during rat cytomegalovirus infection

Bart L. Haagmans^*
, Katja J. Teerds
, Adriana J.M. Van Den Eijnden-Van Raaij
, Marian C. Horzinek
, Virgil E.C.J. Schijns

^*Corresponding author for this work

Utrecht University

Research output: Contribution to journal › Article › Academic › peer-review

20 Citations (Scopus)

Abstract

We analysed the production of transforming growth factor β (TGF-β) during a cytomegalovirus (CMV) infection in a rat model system. Splenocytes from immunocompetent rats infected with rat CMV (RCMV) released increased amounts of TGF-β₁. TGF-β production was also evident in RCMV-infected radiation-immunosuppressed rats; their sera inhibited the interleukin 2-induced proliferation of T cells, which could be restored by anti-TGF-β antibodies. In addition, TGF-β production could be visualized immunohistologically in the lungs, spleen, liver and bone marrow of radiation-immunosuppressed infected rats. The virus directly induced this cytokine since TGF-β was produced upon RCMV infection in vitro. The induction of TGF-β production may contribute to immunosuppression during CMV infection.

Original language	English
Pages (from-to)	205-213
Number of pages	9
Journal	Journal of General Virology
Volume	78
Issue number	1
DOIs	https://doi.org/10.1099/0022-1317-78-1-205
Publication status	Published - 1 Jan 1997
Externally published	Yes

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title = "Transforming growth factor β production during rat cytomegalovirus infection",

abstract = "We analysed the production of transforming growth factor β (TGF-β) during a cytomegalovirus (CMV) infection in a rat model system. Splenocytes from immunocompetent rats infected with rat CMV (RCMV) released increased amounts of TGF-β1. TGF-β production was also evident in RCMV-infected radiation-immunosuppressed rats; their sera inhibited the interleukin 2-induced proliferation of T cells, which could be restored by anti-TGF-β antibodies. In addition, TGF-β production could be visualized immunohistologically in the lungs, spleen, liver and bone marrow of radiation-immunosuppressed infected rats. The virus directly induced this cytokine since TGF-β was produced upon RCMV infection in vitro. The induction of TGF-β production may contribute to immunosuppression during CMV infection.",

author = "Haagmans, \{Bart L.\} and Teerds, \{Katja J.\} and \{Van Den Eijnden-Van Raaij\}, \{Adriana J.M.\} and Horzinek, \{Marian C.\} and Schijns, \{Virgil E.C.J.\}",

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T1 - Transforming growth factor β production during rat cytomegalovirus infection

AU - Haagmans, Bart L.

AU - Teerds, Katja J.

AU - Van Den Eijnden-Van Raaij, Adriana J.M.

AU - Horzinek, Marian C.

AU - Schijns, Virgil E.C.J.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - We analysed the production of transforming growth factor β (TGF-β) during a cytomegalovirus (CMV) infection in a rat model system. Splenocytes from immunocompetent rats infected with rat CMV (RCMV) released increased amounts of TGF-β1. TGF-β production was also evident in RCMV-infected radiation-immunosuppressed rats; their sera inhibited the interleukin 2-induced proliferation of T cells, which could be restored by anti-TGF-β antibodies. In addition, TGF-β production could be visualized immunohistologically in the lungs, spleen, liver and bone marrow of radiation-immunosuppressed infected rats. The virus directly induced this cytokine since TGF-β was produced upon RCMV infection in vitro. The induction of TGF-β production may contribute to immunosuppression during CMV infection.

AB - We analysed the production of transforming growth factor β (TGF-β) during a cytomegalovirus (CMV) infection in a rat model system. Splenocytes from immunocompetent rats infected with rat CMV (RCMV) released increased amounts of TGF-β1. TGF-β production was also evident in RCMV-infected radiation-immunosuppressed rats; their sera inhibited the interleukin 2-induced proliferation of T cells, which could be restored by anti-TGF-β antibodies. In addition, TGF-β production could be visualized immunohistologically in the lungs, spleen, liver and bone marrow of radiation-immunosuppressed infected rats. The virus directly induced this cytokine since TGF-β was produced upon RCMV infection in vitro. The induction of TGF-β production may contribute to immunosuppression during CMV infection.

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DO - 10.1099/0022-1317-78-1-205

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VL - 78

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JO - Journal of General Virology

JF - Journal of General Virology

IS - 1

ER -

Transforming growth factor β production during rat cytomegalovirus infection

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