Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11

Arjan Buijs, Sarah Sherr, Sjozèf van Baal, Saskia van Bezouw, Dorien van der Plas, Ad Geurts van Kessel, Peter Riegman, Ronald Lekanne Deprez, Ellen Zwarthoff, Anne Hagemeijer, Gerard Grosveld*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

In myeloid and lymphoid leukemias recurrent chromosomal aberrations can be detected in chromosome region 12p13. We characterized the genes involved in t(12;22) (p13;q11) in two patients with myeloid leukemia and one with myelodysplastic syndrome (MDS). MN1, a gene on chromosome 22q11 was shown to be fused to TEL, a member of the family of ETS transcription factors on chromosome 12p13. The translocation results in transcription of the reciprocal fusion mRNAs, MN1-TEL and TEL-MN1, of which MN1-TEL is likely to encode an aberrant transcription factor containing the ETS DNA-binding domain of TEL. In addition to fusion of TEL to the PDGFβ receptor in t(5;12) in chronic myelomonocytic leukemia (CMML), our data suggest that the involvement of this protein in myeloid leukemogenesis could be dual; its isolated protein-protein dimerization and DNA-binding domains may be crucial for the oncogenic activation of functionally different fusion proteins.

Original languageEnglish
Pages (from-to)1511-1519
Number of pages9
JournalOncogene
Volume10
Issue number8
Publication statusPublished - 20 Apr 1995

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