Transmission of influenza A/H5N1 viruses in mammals

M Imai, Sander Herfst, Erin Sorrell, Eefje Schrauwen, Martin Linster, Miranda de Graaf, Ron Fouchier, Y Kawaoka

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Abstract

Highly pathogenic avian H5N1 influenza A viruses occasionally infect humans and cause severe respiratory disease and fatalities. Currently, these viruses are not efficiently transmitted from person to person, although limited human-to-human transmission may have occurred. Nevertheless, further adaptation of avian H5N1 influenza A viruses to humans and/or reassortment with human influenza A viruses may result in aerosol transmissible viruses with pandemic potential. Although the full range of factors that modulate the transmission and replication of influenza A viruses in humans are not yet known, we are beginning to understand some of the molecular changes that may allow H5N1 influenza A viruses to transmit via aerosols or respiratory droplets among mammals. A better understanding of the biological basis and genetic determinants that confer transmissibility to H5N1 influenza A viruses in mammals is important to enhance our pandemic preparedness. (C) 2013 Elsevier B.V. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)15-20
Number of pages6
JournalVirus Research
Volume178
Issue number1
DOIs
Publication statusPublished - 2013

Research programs

  • EMC MM-04-27-01

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