Transplant in older adults with AML: genomic wheat and chaff

In this issue of Blood, Murdock et al(1) apply extensive diagnostic molecular profiling and measurable residual disease (MRD) detection of persistent mutations in a real-world cohort of older adults with acute myeloid leukemia (AML) to extract the most useful predictors of relapse-free survival (RFS) after allogeneic transplantation in first remission. Their results indicate that molecular persistence in remission is frequent in older adults and does not retain prognostic value for posttransplant outcomes after adjusting for specific baseline molecular and clinical variables.