Transplantation results of completely HLA-Mismatched living and completely HLA-matched deceased-donor kidneys are comparable

Mirjam Laging*, Judith Kal - van Gestel, GW Haasnoot, FHJ Claas, Jacqueline van de Wetering, J.N.M. IJzermans, Willem Weimar, J.I. Roodnat

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Abstract

BACKGROUND: Human leukocyte antigen (HLA) mismatches are known to influence graft survival in deceased-donor kidney transplantation. We studied the effect of HLA mismatches in a population of recipients of deceased-donor or living-donor kidney transplantations. METHODS: All 1998 transplantations performed in our center between 1990 and 2011 were included in this retrospective cohort study. Four different multivariable Cox proportional hazard analyses were performed with HLA mismatches as continuous variable, as categorical variable (total number of HLA mismatches), as binary variable (zero vs. nonzero HLA mismatches), and HLA-A,-B, and-DR mismatches included separately. RESULTS: Nine hundred ninety-one patients received a deceased-donor kidney and 1007 received a living-donor kidney. In multivariable Cox analysis, HLA mismatches, recipient age, current panel-reactive antibodies, transplant year, donor age, calcineurin inhibitor treatment, and donor type were found to have a significant and independent influence on the risk of graft failure, censored for death. Variables representing the total number of HLA-A,-B, and-DR mismatches had a significant and comparable influence in all analyses. CONCLUSIONS: The influence of HLA mismatches on death-censored graft survival holds true for both deceased-and living-donor kidney transplantation. However, the relative risk of death-censored graft failure of a 2-2-2 mismatched living-donor kidney is comparable with that of a 0-0-0 mismatched deceased-donor kidney.

Original languageEnglish
Pages (from-to)330-336
Number of pages7
JournalTransplantation
Volume97
Issue number3
DOIs
Publication statusPublished - 15 Feb 2014

Research programs

  • EMC MM-04-39-05
  • EMC MM-04-47-07

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