Treatment and survival of patients with small-cell lung cancer: small steps forward, but not for patients > 80

Maryska Heijnen, HAAM Maas, S Siesling, CCE Koning, Jan Willem Coebergh, HJM Groen

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22 Citations (Scopus)

Abstract

Background: Seventy-five percent of newly diagnosed patients with small-cell lung cancer (SCLC) are aged 60+ and quite a few are treated less aggressively because of fear of toxic effects. We described trends in treatment and survival of unselected SCLC patients. Patients and methods: For the present study, all 13 007 SCLC patients aged 60+ diagnosed in The Netherlands from 1997 to 2007 were included. Results: Among patients with limited disease, the proportion receiving chemoradiation increased from 35% to almost 60% for those aged 60-69, from 28% to 48% in age group 70-74, from 17% to 33% in age group 75-79, but remained <10% for those aged 80+. Among patients with extensive disease, the proportion receiving chemotherapy (CT) decreased from 81% of patients aged 60-64 to 23% of those aged 85+, without substantial changes over time. Survival has only improved for patients <80 years. Conclusions: CT (+radiotherapy) has improved survival for unselected SCLC patients <80. A better understanding of the impact of frailty on completion of treatment and toxic effects among patients aged 80+ would enable the treating physician to anticipate toxic effects better and to discuss risks and benefits of treatment with the patient.
Original languageUndefined/Unknown
Pages (from-to)954-960
Number of pages7
JournalAnnals of Oncology
Volume23
Issue number4
DOIs
Publication statusPublished - 2012

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