Treatment of colon cancer in rats with rMuTNF and the interferon-inducer bropirimine

R. L. Marquet; R. W.F. de Bruin; A. M.M. Eggermont; J. Jeekel

doi:10.1007/BF02126589

Treatment of colon cancer in rats with rMuTNF and the interferon-inducer bropirimine

R. L. Marquet^*, R. W.F. de Bruin, A. M.M. Eggermont, J. Jeekel

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic

2 Citations (Scopus)

Abstract

It is well documented that the antitumor activity of tumor necrosis factor (TNF) is improved by interferons (IFN's). Bropirimine (BP) is an immune response modifier which induces IFN. Both TNF and BP have the capacity to inhibit the growth of a transplantable colon tumor (CC 531) in inbred WAG rats. In the present study their combined use was investigated in a one-week assay, with the tumor implanted under the renal capsule. The results indicate that BP, given on days 0 and 1, and 1 μg TNF on days 0, 2 and 4 act additively, leading to an almost complete inhibition of tumor growth.

Original language	English
Pages (from-to)	151-152
Number of pages	2
Journal	Agents and Actions
Volume	26
Issue number	1-2
DOIs	https://doi.org/10.1007/BF02126589
Publication status	Published - Jan 1989

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title = "Treatment of colon cancer in rats with rMuTNF and the interferon-inducer bropirimine",

abstract = "It is well documented that the antitumor activity of tumor necrosis factor (TNF) is improved by interferons (IFN's). Bropirimine (BP) is an immune response modifier which induces IFN. Both TNF and BP have the capacity to inhibit the growth of a transplantable colon tumor (CC 531) in inbred WAG rats. In the present study their combined use was investigated in a one-week assay, with the tumor implanted under the renal capsule. The results indicate that BP, given on days 0 and 1, and 1 μg TNF on days 0, 2 and 4 act additively, leading to an almost complete inhibition of tumor growth.",

author = "Marquet, {R. L.} and {de Bruin}, {R. W.F.} and Eggermont, {A. M.M.} and J. Jeekel",

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AU - Marquet, R. L.

AU - de Bruin, R. W.F.

AU - Eggermont, A. M.M.

AU - Jeekel, J.

PY - 1989/1

Y1 - 1989/1

N2 - It is well documented that the antitumor activity of tumor necrosis factor (TNF) is improved by interferons (IFN's). Bropirimine (BP) is an immune response modifier which induces IFN. Both TNF and BP have the capacity to inhibit the growth of a transplantable colon tumor (CC 531) in inbred WAG rats. In the present study their combined use was investigated in a one-week assay, with the tumor implanted under the renal capsule. The results indicate that BP, given on days 0 and 1, and 1 μg TNF on days 0, 2 and 4 act additively, leading to an almost complete inhibition of tumor growth.

AB - It is well documented that the antitumor activity of tumor necrosis factor (TNF) is improved by interferons (IFN's). Bropirimine (BP) is an immune response modifier which induces IFN. Both TNF and BP have the capacity to inhibit the growth of a transplantable colon tumor (CC 531) in inbred WAG rats. In the present study their combined use was investigated in a one-week assay, with the tumor implanted under the renal capsule. The results indicate that BP, given on days 0 and 1, and 1 μg TNF on days 0, 2 and 4 act additively, leading to an almost complete inhibition of tumor growth.

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EP - 152

JO - Agents and Actions

JF - Agents and Actions

IS - 1-2

ER -

Treatment of colon cancer in rats with rMuTNF and the interferon-inducer bropirimine

Abstract

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