Treatment pathway analysis of newly diagnosed dementia patients in four electronic health record databases in Europe

G James, E Collin, M Lawrance, A Mueller, J Podhorna, L Zaremba-Pechmann, Peter Rijnbeek, Johan Lei, Paul Avillach, L Pedersen, D Ansell, A Pasqua, M Mosseveld, Solène Grosdidier, U Gungabissoon, P Egger, R Stewart, C Celis-Morales, M Alexander, G NovakMF Gordon

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Purpose: Real-world studies to describe the use of first, second and third line therapies for the management and symptomatic treatment of dementia are lacking. This retrospective cohort study describes the first-, second- and third-line therapies used for the management and symptomatic treatment of dementia, and in particular Alzheimer’s Disease. Methods: Medical records of patients with newly diagnosed dementia between 1997 and 2017 were collected using four databases from the UK, Denmark, Italy and the Netherlands. Results: We identified 191,933 newly diagnosed dementia patients in the four databases between 1997 and 2017 with 39,836 (IPCI (NL): 3281, HSD (IT): 1601, AUH (DK): 4474, THIN (UK): 30,480) fulfilling the inclusion criteria, and of these, 21,131 had received a specific diagnosis of Alzheimer’s disease. The most common first line therapy initiated within a year (± 365 days) of diagnosis were Acetylcholinesterase inhibitors, namely rivastigmine in IPCI, donepezil in HSD and the THIN and the N-methyl-d-aspartate blocker memantine in AUH. Conclusion: We provide a real-world insight into the heterogeneous management and treatment pathways of newly diagnosed dementia patients and a subset of Alzheimer’s Disease patients from across Europe.

Original languageEnglish
Pages (from-to)409-416
Number of pages8
JournalSocial Psychiatry and Psychiatric Epidemiology
Volume56
Issue number3
DOIs
Publication statusPublished - Mar 2021

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