Trends in Distal Esophageal and Gastroesophageal Junction Cancer Care: The Dutch Nationwide Ivory Study

Marianne C. Kalff*, Mark I. Van Berge Henegouwen, Peter C. Baas, Renu R. Bahadoer, Eric J.T. Belt, Baukje Brattinga, Linda Claassen, Admira Ćosović, David Crull, Freek Daams, Annette D. Van Dalsen, Jan Willem T. Dekker, Marc J. Van Det, Manon Drost, Peter Van Duijvendijk, Wietse J. Eshuis, Stijn Van Esser, Marcia P. Gaspersz, Burak Görgec, Richard P.R. GroenendijkHenk H. Hartgrink, Erwin Van Der Harst, Jan Willem Haveman, Joos Heisterkamp, Richard Van Hillegersberg, Wendy Kelder, B. Feike Kingma, Willem J. Koemans, Ewout A. Kouwenhoven, Sjoerd M. Lagarde, Frederik Lecot, Philip P. Van Der Linden, Misha D.P. Luyer, Grard A.P. Nieuwenhuijzen, Pim B. Olthof, Donald L. Van Der Peet, Jean Pierre E.N. Pierie, E. G.J.M.Robert Pierik, Victor D. Plat, Fatih Polat, Camiel Rosman, Jelle P. Ruurda, Johanna W. Van Sandick, Rene Scheer, Cettela A.M. Slootmans, Meindert N. Sosef, Odin V. Sosef, Wobbe O. De Steur, Hein B.A.C. Stockmann, Fanny J. Stoop, Daan M. Voeten, Guusje Vugts, Guy H.E.J. Vijgen, Víola B. Weeda, Marinus J. Wiezer, Martijn G.H. Van Oijen, Suzanne S. Gisbertz

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)


Objective: This study evaluated the nationwide trends in care and accompanied postoperative outcomes for patients with distal esophageal and gastro-esophageal junction cancer. Summary of Background Data: The introduction of transthoracic esophagectomy, minimally invasive surgery, and neo-adjuvant chemo(radio)therapy changed care for patients with esophageal cancer. Methods: Patients after elective transthoracic and transhiatal esophagectomy for distal esophageal or gastroesophageal junction carcinoma in the Netherlands between 2007-2016 were included. The primary aim was to evaluate trends in both care and postoperative outcomes for the included patients. Additionally, postoperative outcomes after transthoracic and tran-shiatal esophagectomy were compared, stratified by time periods. Results: Among 4712 patients included, 74% had distal esophageal tumors and 87% had adenocarcinomas. Between 2007 and 2016, the proportion of transthoracic esophagectomy increased from 41% to 81%, and neo-adjuvant treatment and minimally invasive esophagectomy increased from 31% to 96%, and from 7% to 80%, respectively. Over this 10-year period, postoperative outcomes improved: postoperative morbidity decreased from 66.6% to 61.8% (P = 0.001), R0 resection rate increased from 90.0% to 96.5% (P <0.001), median lymph node harvest increased from 15 to 19 (P <0.001), and median survival increased from 35 to 41 months (P = 0.027). Conclusion: In this nationwide cohort, a transition towards more neo-adju-vant treatment, transthoracic esophagectomy and minimally invasive surgery was observed over a 10-year period, accompanied by decreased postoperative morbidity, improved surgical radicality and lymph node harvest, and improved survival.

Original languageEnglish
Pages (from-to)619-628
Number of pages10
JournalAnnals of Surgery
Issue number4
Publication statusPublished - 1 Apr 2023

Bibliographical note

Funding Information:
Luyer received research grants from Galvani and Medtronic. Nieuwenhuijzen reports consulting fees and research grants from Medtronic. Rosman has received research grants from Johnson&Johnson and Medtronic. van Berge Henegouwen reports research grants from Olympus and Stryker, in addition to consulting fees from Medtronic, Alesi Surgical, Johnson&Johnson and Mylan. van Oijen has received unrestricted research grants from Bayer, Lilly, Merck Serono, Nordic, Servier, and Roche. The remaining authors have no conflict of interest to report. No funding was received for this study.

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