Trial design and endpoints in clinical transplant research

Simon R. Knight*, Peter J. Morris, Stefan Schneeberger, Liset H.M. Pengel

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

20 Citations (Scopus)

Abstract

The number of clinical trials in solid organ transplantation is progressively increasing year on year, but the quality of design and reporting still varies considerably. The constraints on organ availability, improving short-term outcomes, ethics and timescales involved in organ transplantation present unique challenges for trials in this field. An understanding of the methodology and potential pitfalls in clinical research is essential both to interpret trial results and to design robust studies. This review summarizes the scope and quality of reporting in existing transplant clinical trials and details aspects of clinical trial methodology with particular relevance to transplantation. We highlight initiatives designed to improve the quality of this process to ensure that the results of clinical trials are robust, well reported and of use in everyday clinical practice.

Original languageEnglish
Pages (from-to)870-879
Number of pages10
JournalTransplant International
Volume29
Issue number8
DOIs
Publication statusPublished - Aug 2016
Externally publishedYes

Bibliographical note

Publisher Copyright: © 2016 Steunstichting ESOT

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