@article{c2f7393a7c3e410a8c2ff424a9db3fe6,
title = "Tricuspid Valve Academic Research Consortium Definitions for Tricuspid Regurgitation and Trial Endpoints",
abstract = "Interest in the pathophysiology, etiology, management, and outcomes of patients with tricuspid regurgitation (TR) has grown in the wake of multiple natural history studies showing progressively worse outcomes associated with increasing TR severity, even after adjusting for multiple comorbidities. Historically, isolated tricuspid valve surgery has been associated with high in-hospital mortality rates, leading to the development of transcatheter treatment options. The aim of this first Tricuspid Valve Academic Research Consortium document is to standardize definitions of disease etiology and severity, as well as endpoints for trials that aim to address the gaps in our knowledge related to identification and management of patients with TR. Standardizing endpoints for trials should provide consistency and enable meaningful comparisons between clinical trials. A second Tricuspid Valve Academic Research Consortium document will focus on further defining trial endpoints and will discuss trial design options.",
author = "Hahn, {Rebecca T.} and Lawlor, {Matthew K.} and Davidson, {Charles J.} and Vinay Badhwar and Anna Sannino and Ernest Spitzer and Philipp Lurz and Lindman, {Brian R.} and Yan Topilsky and Baron, {Suzanne J.} and Scott Chadderdon and Khalique, {Omar K.} and Tang, {Gilbert H.L.} and Maurizio Taramasso and Grayburn, {Paul A.} and Luigi Badano and Jonathon Leipsic and Lindenfeld, {Jo Ann} and Stephan Windecker and Sreekanth Vemulapalli and Bjorn Redfors and Alu, {Maria C.} and Cohen, {David J.} and Josep Rod{\'e}s-Cabau and Gorav Ailawadi and Michael Mack and Ori Ben-Yehuda and Leon, {Martin B.} and J{\"o}rg Hausleiter and {TVARC Steering Committee} and Suzanne Arnold and Vinayak Bapat and Natalia Berry and Philipp Blanke and Daniel Burkhoff and Megan Coylewright and Neal Duggal and Benjamin Galper and Isaac George and Mayra Guerrero and Nadira Hamid and Vikrant Jagadeesan and Susheel Kodali and Mitch Krucoff and Roberto Lang and Mahesh Madhavan and Vallerie McLaughin and Roxana Mehran and Francois Philippon and Sethi, {Sanjum S.} and Robert Smith",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
month = oct,
day = "24",
doi = "10.1016/j.jacc.2023.08.008",
language = "English",
volume = "82",
pages = "1711--1735",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier Inc.",
number = "17",
}