Triple Therapy Protocol for Primary and Secondary Auricular Keloids: A Prospective Outcome Evaluation

Frank R. Datema, Joan Saridin, Ferdinand C.A. Timmer, Laura T. Rothuizen, Floris V.W.J. van Zijl

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Ear keloid lesions present a significant challenge to the aesthetic surgeon. Keloids are known to recur and can cause severe cosmetic, functional, and psychological impairments. Several adjuvants to surgical removal have been promoted, with varying recurrence rates. OBJECTIVE: To evaluate the effectiveness of triple therapy to treat secondary (and large primary) auricular keloids. 


Patients with secondary or large primary auricular keloids undergoing triple therapy were prospectively studied. Keloids were excised intramarginally under magnification and repeated triamcinolone acetonide 40 mg/mL injections were administered, followed by the application of a custom-made acrylate pressure device. Recurrent keloid formation and adverse events were monitored during a minimum of 6 months of follow-up. 


Sixteen auricular keloid lesions (3 large primary and 13 secondary) were subjected to the proposed technique with a mean follow-up of 28 months. All cases that adhered to the protocol were free of keloid after triple therapy. Side effects were limited to 1 case of lobular atrophy and slight hypopigmentation. All patients were satisfied with the results. 


The triple therapy protocol is highly effective in primary and secondary auricular keloid as long as patients remain compliant.

Original languageEnglish
Pages (from-to)838-843
Number of pages6
JournalDermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
Issue number9
Publication statusPublished - 1 Sept 2023

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