Tumour basement membrane laminin expression predicts outcome following curative resection of pancreatic head cancer

JA Zee, Casper van Eijck, Hop, Katharina Biermann, Bilyana Dicheva, Ann Seynhaeve, Gerben Koning, Lex Eggermont, Timo ten Hagen

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BACKGROUND: Although widely fragmented BMs have been associated with adverse outcome in several cancer types, comparatively little is known with respect to its effect on the prognosis of pancreatic cancer. The aim of the current study was therefore to determine the prognostic value of tumour basement membrane (BM) continuity in two anatomically closely related, however, prognostically different tumours, pancreatic head- and periampullary cancer. METHODS: Tumour BM continuity was determined by immunohistochemical staining of its two major components, laminin and collagen type IV. Associations were made with recurrence free survival (RFS), cancer-specific survival (CSS), overall survival (OS) and conventional prognostic factors. RESULTS: Fifty-nine and 61% of pancreatic head and periampullary tumours, respectively, showed limited BM laminin expression. Whereas 43% and 41% of pancreatic head and periampullary cancers, respectively, showed limited BM collagen type IV expression. Limited BM laminin was associated with poor outcome following curative resection of pancreatic head cancer (P = 0.034, 0.013 and 0.017 for RFS, CSS and OS, respectively). Two and a half times as many patients with >= 25% BM laminin were recurrence CONCLUSION: Discontinuous BMs, determined by laminin expression, are associated with poor outcome following curative resection of pancreatic head cancer. British Journal of Cancer (2012) 107, 1153-1158. doi:10.1038/bjc.2012.373 www.bjcancer.com Published online 28 August 2012 (c) 2012 Cancer Research UK
Original languageUndefined/Unknown
Pages (from-to)1153-1158
Number of pages6
JournalBritish Journal of Cancer
Issue number7
Publication statusPublished - 2012

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