Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion

J. H.W. De Wilt, T. L.M. Ten Hagen, G. De Boeck, S. T. Van Tiel, E. A. De Bruijn, A. M.M. Eggermont*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-α) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-α was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-α in ILP. (C) 2000 Cancer Research Campaign.

Original languageEnglish
Pages (from-to)1000-1003
Number of pages4
JournalBritish Journal of Cancer
Volume82
Issue number5
DOIs
Publication statusPublished - 3 Feb 2000

Bibliographical note

Funding Information: This work was financed in part by a grant from the Dutch Cancer Society. Boehringer Ingelheim GmbH is acknowledged for generously providing TNF-a.

This paper was modified 12 months after initial publication to switch to Creative Commons licence terms, as noted at publication

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