Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion

J. H.W. De Wilt; T. L.M. Ten Hagen; G. De Boeck; S. T. Van Tiel; E. A. De Bruijn; A. M.M. Eggermont

doi:10.1054/bjoc.1999.1032

Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion

J. H.W. De Wilt, T. L.M. Ten Hagen, G. De Boeck, S. T. Van Tiel, E. A. De Bruijn, A. M.M. Eggermont^*

^*Corresponding author for this work

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Abstract

Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-α) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-α was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-α in ILP. (C) 2000 Cancer Research Campaign.

Original language	English
Pages (from-to)	1000-1003
Number of pages	4
Journal	British Journal of Cancer
Volume	82
Issue number	5
DOIs	https://doi.org/10.1054/bjoc.1999.1032
Publication status	Published - 3 Feb 2000

Bibliographical note

Funding Information: This work was financed in part by a grant from the Dutch Cancer Society. Boehringer Ingelheim GmbH is acknowledged for generously providing TNF-a.

This paper was modified 12 months after initial publication to switch to Creative Commons licence terms, as noted at publication

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6691032Final published version, 220 KBLicence: CC BY

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title = "Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion",

abstract = "Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-α) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-α was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-α in ILP. (C) 2000 Cancer Research Campaign.",

author = "{De Wilt}, {J. H.W.} and {Ten Hagen}, {T. L.M.} and {De Boeck}, G. and {Van Tiel}, {S. T.} and {De Bruijn}, {E. A.} and Eggermont, {A. M.M.}",

note = "Funding Information: This work was financed in part by a grant from the Dutch Cancer Society. Boehringer Ingelheim GmbH is acknowledged for generously providing TNF-a. This paper was modified 12 months after initial publication to switch to Creative Commons licence terms, as noted at publication",

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doi = "10.1054/bjoc.1999.1032",

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AU - De Wilt, J. H.W.

AU - Ten Hagen, T. L.M.

AU - De Boeck, G.

AU - Van Tiel, S. T.

AU - De Bruijn, E. A.

AU - Eggermont, A. M.M.

N1 - Funding Information: This work was financed in part by a grant from the Dutch Cancer Society. Boehringer Ingelheim GmbH is acknowledged for generously providing TNF-a. This paper was modified 12 months after initial publication to switch to Creative Commons licence terms, as noted at publication

PY - 2000/2/3

Y1 - 2000/2/3

N2 - Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-α) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-α was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-α in ILP. (C) 2000 Cancer Research Campaign.

AB - Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-α) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-α was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-α in ILP. (C) 2000 Cancer Research Campaign.

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JF - British Journal of Cancer

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Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion

Abstract

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