Two bifunctional desferrioxamine chelators for bioorthogonal labeling of biovectors with zirconium-89

F. Gao; C. Ieritano; K. T. Chen; G. M. Dias; J. Rousseau; F. Bénard; Y. Seimbille

doi:10.1039/c8ob01434e

Two bifunctional desferrioxamine chelators for bioorthogonal labeling of biovectors with zirconium-89

F. Gao, C. Ieritano, K. T. Chen, G. M. Dias, J. Rousseau, F. Bénard, Y. Seimbille^*

^*Corresponding author for this work

Radiology & Nuclear Medicine

Research output: Contribution to journal › Article › Academic › peer-review

8 Citations (Scopus)

Abstract

We report two bifunctional chelators, DFO-Cys and DFO-CBT, to label biovectors with zirconium-89 according to the 2-cyanobenzothiazole/1,2-aminothiol cycloaddition. Their features are high labeling yields, rapid and efficient bioconjugation, metabolically stable luciferin-based end products, and applicability to orthogonal two-step labeling of sensitive biomolecules.

Original language	English
Pages (from-to)	5102-5106
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	16
Issue number	28
DOIs	https://doi.org/10.1039/c8ob01434e
Publication status	Published - 2018

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry.

Access to Document

10.1039/c8ob01434e

Cite this

@article{be45f4fdf05f4232a6b02fbb6be584b3,

title = "Two bifunctional desferrioxamine chelators for bioorthogonal labeling of biovectors with zirconium-89",

abstract = "We report two bifunctional chelators, DFO-Cys and DFO-CBT, to label biovectors with zirconium-89 according to the 2-cyanobenzothiazole/1,2-aminothiol cycloaddition. Their features are high labeling yields, rapid and efficient bioconjugation, metabolically stable luciferin-based end products, and applicability to orthogonal two-step labeling of sensitive biomolecules.",

author = "F. Gao and C. Ieritano and Chen, {K. T.} and Dias, {G. M.} and J. Rousseau and F. B{\'e}nard and Y. Seimbille",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2018",

doi = "10.1039/c8ob01434e",

language = "English",

volume = "16",

pages = "5102--5106",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "28",

}

TY - JOUR

T1 - Two bifunctional desferrioxamine chelators for bioorthogonal labeling of biovectors with zirconium-89

AU - Gao, F.

AU - Ieritano, C.

AU - Chen, K. T.

AU - Dias, G. M.

AU - Rousseau, J.

AU - Bénard, F.

AU - Seimbille, Y.

PY - 2018

Y1 - 2018

N2 - We report two bifunctional chelators, DFO-Cys and DFO-CBT, to label biovectors with zirconium-89 according to the 2-cyanobenzothiazole/1,2-aminothiol cycloaddition. Their features are high labeling yields, rapid and efficient bioconjugation, metabolically stable luciferin-based end products, and applicability to orthogonal two-step labeling of sensitive biomolecules.

AB - We report two bifunctional chelators, DFO-Cys and DFO-CBT, to label biovectors with zirconium-89 according to the 2-cyanobenzothiazole/1,2-aminothiol cycloaddition. Their features are high labeling yields, rapid and efficient bioconjugation, metabolically stable luciferin-based end products, and applicability to orthogonal two-step labeling of sensitive biomolecules.

UR - http://www.scopus.com/inward/record.url?scp=85050349360&partnerID=8YFLogxK

U2 - 10.1039/c8ob01434e

DO - 10.1039/c8ob01434e

M3 - Article

C2 - 29974105

AN - SCOPUS:85050349360

SN - 1477-0520

VL - 16

SP - 5102

EP - 5106

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 28

ER -

Two bifunctional desferrioxamine chelators for bioorthogonal labeling of biovectors with zirconium-89

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this