Two bifunctional desferrioxamine chelators for bioorthogonal labeling of biovectors with zirconium-89

F. Gao; C. Ieritano; K. T. Chen; G. M. Dias; J. Rousseau; F. Bénard; Y. Seimbille

doi:10.1039/c8ob01434e

Two bifunctional desferrioxamine chelators for bioorthogonal labeling of biovectors with zirconium-89

F. Gao
, C. Ieritano
, K. T. Chen
, G. M. Dias
, J. Rousseau
, F. Bénard
, Y. Seimbille^*

^*Corresponding author for this work

Radiology & Nuclear Medicine

Research output: Contribution to journal › Article › Academic › peer-review

8 Citations (Scopus)

Abstract

We report two bifunctional chelators, DFO-Cys and DFO-CBT, to label biovectors with zirconium-89 according to the 2-cyanobenzothiazole/1,2-aminothiol cycloaddition. Their features are high labeling yields, rapid and efficient bioconjugation, metabolically stable luciferin-based end products, and applicability to orthogonal two-step labeling of sensitive biomolecules.

Original language	English
Pages (from-to)	5102-5106
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	16
Issue number	28
DOIs	https://doi.org/10.1039/c8ob01434e
Publication status	Published - 2018

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© The Royal Society of Chemistry.

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abstract = "We report two bifunctional chelators, DFO-Cys and DFO-CBT, to label biovectors with zirconium-89 according to the 2-cyanobenzothiazole/1,2-aminothiol cycloaddition. Their features are high labeling yields, rapid and efficient bioconjugation, metabolically stable luciferin-based end products, and applicability to orthogonal two-step labeling of sensitive biomolecules.",

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T1 - Two bifunctional desferrioxamine chelators for bioorthogonal labeling of biovectors with zirconium-89

AU - Gao, F.

AU - Ieritano, C.

AU - Chen, K. T.

AU - Dias, G. M.

AU - Rousseau, J.

AU - Bénard, F.

AU - Seimbille, Y.

PY - 2018

Y1 - 2018

N2 - We report two bifunctional chelators, DFO-Cys and DFO-CBT, to label biovectors with zirconium-89 according to the 2-cyanobenzothiazole/1,2-aminothiol cycloaddition. Their features are high labeling yields, rapid and efficient bioconjugation, metabolically stable luciferin-based end products, and applicability to orthogonal two-step labeling of sensitive biomolecules.

AB - We report two bifunctional chelators, DFO-Cys and DFO-CBT, to label biovectors with zirconium-89 according to the 2-cyanobenzothiazole/1,2-aminothiol cycloaddition. Their features are high labeling yields, rapid and efficient bioconjugation, metabolically stable luciferin-based end products, and applicability to orthogonal two-step labeling of sensitive biomolecules.

UR - https://www.scopus.com/pages/publications/85050349360

U2 - 10.1039/c8ob01434e

DO - 10.1039/c8ob01434e

M3 - Article

C2 - 29974105

AN - SCOPUS:85050349360

SN - 1477-0520

VL - 16

SP - 5102

EP - 5106

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 28

ER -

Two bifunctional desferrioxamine chelators for bioorthogonal labeling of biovectors with zirconium-89

Abstract

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