Two Cases of Intraocular Undifferentiated Pleomorphic Sarcoma

Sodaba Khatab; Johanna Maria Colijn; Nicole Naus; Robert M. Verdijk; Gijsbert Hötte

doi:10.1159/000541063

Two Cases of Intraocular Undifferentiated Pleomorphic Sarcoma

Sodaba Khatab^*
, Johanna Maria Colijn
, Nicole Naus
, Robert M. Verdijk
, Gijsbert Hötte

^*Corresponding author for this work

The Rotterdam Eye Hospital
Leiden University Medical Centre

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

73 Downloads (Pure)

Abstract

Introduction: Undifferentiated pleomorphic sarcoma (UPS), formerly known as malignant fibrous histiocytoma, is a highgrade soft tissue sarcoma arising from mesenchymal stem cells. UPSs are rare and account for about 5% of all soft tissue sarcoma. UPSs arising in the head and neck are especially rare, comprising 1-3% of all UPSs.

Case Presentation: In this report, we describe 2 cases of intraocular UPS. Both cases concern 68-year-old males: one developing a UPS in an eviscerated socket after a chronic fibrinous inflammation and the other years after ocular trauma.

Conclusion: Our cases may support the hypothesis of chronic inflammation playing a role in sarcoma formation as they are characterized by a longstanding history of (surgical) trauma with signs of chronic inflammation and phthisis bulbi.

Original language	English
Pages (from-to)	227-233
Number of pages	7
Journal	Ocular Oncology and Pathology
Volume	10
Issue number	4
Early online date	27 Sept 2024
DOIs	https://doi.org/10.1159/000541063
Publication status	Published - 1 Dec 2024

Bibliographical note

Access to Document

10.1159/000541063Licence: CC BY

000541063Final published version, 0.98 MBLicence: CC BY

Cite this

@article{82074df5cce24d4fa6e3792845e3b17f,

title = "Two Cases of Intraocular Undifferentiated Pleomorphic Sarcoma",

abstract = "Introduction: Undifferentiated pleomorphic sarcoma (UPS), formerly known as malignant fibrous histiocytoma, is a highgrade soft tissue sarcoma arising from mesenchymal stem cells. UPSs are rare and account for about 5\% of all soft tissue sarcoma. UPSs arising in the head and neck are especially rare, comprising 1-3\% of all UPSs. Case Presentation: In this report, we describe 2 cases of intraocular UPS. Both cases concern 68-year-old males: one developing a UPS in an eviscerated socket after a chronic fibrinous inflammation and the other years after ocular trauma. Conclusion: Our cases may support the hypothesis of chronic inflammation playing a role in sarcoma formation as they are characterized by a longstanding history of (surgical) trauma with signs of chronic inflammation and phthisis bulbi.",

author = "Sodaba Khatab and Colijn, \{Johanna Maria\} and Nicole Naus and Verdijk, \{Robert M.\} and Gijsbert H{\"o}tte",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s).",

year = "2024",

month = dec,

day = "1",

doi = "10.1159/000541063",

language = "English",

volume = "10",

pages = "227--233",

journal = "Ocular Oncology and Pathology",

issn = "2296-4681",

publisher = "Karger",

number = "4",

}

TY - JOUR

T1 - Two Cases of Intraocular Undifferentiated Pleomorphic Sarcoma

AU - Khatab, Sodaba

AU - Colijn, Johanna Maria

AU - Naus, Nicole

AU - Verdijk, Robert M.

AU - Hötte, Gijsbert

PY - 2024/12/1

Y1 - 2024/12/1

N2 - Introduction: Undifferentiated pleomorphic sarcoma (UPS), formerly known as malignant fibrous histiocytoma, is a highgrade soft tissue sarcoma arising from mesenchymal stem cells. UPSs are rare and account for about 5% of all soft tissue sarcoma. UPSs arising in the head and neck are especially rare, comprising 1-3% of all UPSs. Case Presentation: In this report, we describe 2 cases of intraocular UPS. Both cases concern 68-year-old males: one developing a UPS in an eviscerated socket after a chronic fibrinous inflammation and the other years after ocular trauma. Conclusion: Our cases may support the hypothesis of chronic inflammation playing a role in sarcoma formation as they are characterized by a longstanding history of (surgical) trauma with signs of chronic inflammation and phthisis bulbi.

AB - Introduction: Undifferentiated pleomorphic sarcoma (UPS), formerly known as malignant fibrous histiocytoma, is a highgrade soft tissue sarcoma arising from mesenchymal stem cells. UPSs are rare and account for about 5% of all soft tissue sarcoma. UPSs arising in the head and neck are especially rare, comprising 1-3% of all UPSs. Case Presentation: In this report, we describe 2 cases of intraocular UPS. Both cases concern 68-year-old males: one developing a UPS in an eviscerated socket after a chronic fibrinous inflammation and the other years after ocular trauma. Conclusion: Our cases may support the hypothesis of chronic inflammation playing a role in sarcoma formation as they are characterized by a longstanding history of (surgical) trauma with signs of chronic inflammation and phthisis bulbi.

UR - https://www.scopus.com/pages/publications/85208557455

U2 - 10.1159/000541063

DO - 10.1159/000541063

M3 - Article

C2 - 39660252

AN - SCOPUS:85208557455

SN - 2296-4681

VL - 10

SP - 227

EP - 233

JO - Ocular Oncology and Pathology

JF - Ocular Oncology and Pathology

IS - 4

ER -

Two Cases of Intraocular Undifferentiated Pleomorphic Sarcoma

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this