Two Cases of Viral Re-suppression After M184V+R263K Selection on Dolutegravir/Lamivudine Without Treatment Modification

Axel Ursenbach; Yvon Ruch; Baptiste Hoellinger; Anne Fuchs; Stephanie Caspar; Frederick Jegou; David Rey; Samira Fafi-Kremer; Thibault Mesplede; Pierre Gantner

doi:10.1093/cid/ciae006

Two Cases of Viral Re-suppression After M184V+R263K Selection on Dolutegravir/Lamivudine Without Treatment Modification

Axel Ursenbach, Yvon Ruch, Baptiste Hoellinger, Anne Fuchs, Stephanie Caspar, Frederick Jegou, David Rey, Samira Fafi-Kremer, Thibault Mesplede, Pierre Gantner

Virology

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Web of Science)

Abstract

Dolutegravir/lamivudine (DTG/3TC) has a high genetic barrier against the development of human immunodeficiency virus drug resistance. We report 2 cases of R263K + M184V mutations during DTG/3TC failure followed by viral suppression after adherence intervention without treatment change that we attribute to residual drug activity, reduced viral fitness, and robust immune competence.

Original language	English
Article number	ciae006
Pages (from-to)	198-201
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	79
Issue number	1
Early online date	9 Jan 2024
DOIs	https://doi.org/10.1093/cid/ciae006
Publication status	Published - 15 Jul 2024

Bibliographical note

Publisher Copyright:
© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved.

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ciae006Final published version, 403 KBLicence: Article 25fa Dutch Copyright Act

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AU - Fuchs, Anne

AU - Caspar, Stephanie

AU - Jegou, Frederick

AU - Rey, David

AU - Fafi-Kremer, Samira

AU - Mesplede, Thibault

AU - Gantner, Pierre

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Two Cases of Viral Re-suppression After M184V+R263K Selection on Dolutegravir/Lamivudine Without Treatment Modification

Abstract

Bibliographical note

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