Type 2 Diabetes Mellitus and Vertebral Fracture Risk

Fjorda Koromani; Samuel Ghatan; Mandy van Hoek; M.C. Zillikens; Edwin Oei; Fernando Rivadeneira; Ling Oei - Oei

doi:10.1007/s11914-020-00646-8

Type 2 Diabetes Mellitus and Vertebral Fracture Risk

Fjorda Koromani, Samuel Ghatan, Mandy van Hoek, M.C. Zillikens, Edwin Oei, Fernando Rivadeneira, Ling Oei - Oei

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Purpose of Review: The purpose of this review is to summarize the recently published evidence concerning vertebral fracture risk in individuals with diabetes mellitus. Recent Findings: Vertebral fracture risk is increased in individuals with T2DM. The presence of vertebral fractures in T2DM is associated with increased non-vertebral fracture risk and mortality. TBS could be helpful to estimate vertebral fracture risk in individuals with T2DM. An increased amount of bone marrow fat has been implicated in bone fragility in T2DM. Results from two recent studies show that both teriparatide and denosumab are effective in reducing vertebral fracture risk also in individuals with T2DM. Summary: Individuals with T2DM could benefit from systematic screening in the clinic for presence of vertebral fractures.

Original language	English
Pages (from-to)	50-57
Number of pages	8
Journal	Current Osteoporosis Reports
Volume	19
Issue number	1
DOIs	https://doi.org/10.1007/s11914-020-00646-8
Publication status	Published - 12 Jan 2021

Bibliographical note

Funding Information:
S.G. is funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 860898. L.O. is funded by an Erasmus MC fellowship grant.

Publisher Copyright:
© 2021, The Author(s).

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Cite this

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title = "Type 2 Diabetes Mellitus and Vertebral Fracture Risk",

abstract = "Purpose of Review: The purpose of this review is to summarize the recently published evidence concerning vertebral fracture risk in individuals with diabetes mellitus. Recent Findings: Vertebral fracture risk is increased in individuals with T2DM. The presence of vertebral fractures in T2DM is associated with increased non-vertebral fracture risk and mortality. TBS could be helpful to estimate vertebral fracture risk in individuals with T2DM. An increased amount of bone marrow fat has been implicated in bone fragility in T2DM. Results from two recent studies show that both teriparatide and denosumab are effective in reducing vertebral fracture risk also in individuals with T2DM. Summary: Individuals with T2DM could benefit from systematic screening in the clinic for presence of vertebral fractures.",

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AU - Koromani, Fjorda

AU - Ghatan, Samuel

AU - van Hoek, Mandy

AU - Zillikens, M.C.

AU - Oei, Edwin

AU - Rivadeneira, Fernando

AU - Oei - Oei, Ling

N1 - Funding Information: S.G. is funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 860898. L.O. is funded by an Erasmus MC fellowship grant. Publisher Copyright: © 2021, The Author(s).

PY - 2021/1/12

Y1 - 2021/1/12

N2 - Purpose of Review: The purpose of this review is to summarize the recently published evidence concerning vertebral fracture risk in individuals with diabetes mellitus. Recent Findings: Vertebral fracture risk is increased in individuals with T2DM. The presence of vertebral fractures in T2DM is associated with increased non-vertebral fracture risk and mortality. TBS could be helpful to estimate vertebral fracture risk in individuals with T2DM. An increased amount of bone marrow fat has been implicated in bone fragility in T2DM. Results from two recent studies show that both teriparatide and denosumab are effective in reducing vertebral fracture risk also in individuals with T2DM. Summary: Individuals with T2DM could benefit from systematic screening in the clinic for presence of vertebral fractures.

AB - Purpose of Review: The purpose of this review is to summarize the recently published evidence concerning vertebral fracture risk in individuals with diabetes mellitus. Recent Findings: Vertebral fracture risk is increased in individuals with T2DM. The presence of vertebral fractures in T2DM is associated with increased non-vertebral fracture risk and mortality. TBS could be helpful to estimate vertebral fracture risk in individuals with T2DM. An increased amount of bone marrow fat has been implicated in bone fragility in T2DM. Results from two recent studies show that both teriparatide and denosumab are effective in reducing vertebral fracture risk also in individuals with T2DM. Summary: Individuals with T2DM could benefit from systematic screening in the clinic for presence of vertebral fractures.

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Type 2 Diabetes Mellitus and Vertebral Fracture Risk

Abstract

Bibliographical note

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UN SDGs

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