Type I IFN signature in primary Sjogren's syndrome patients

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Abstract

Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease characterized by lymphocytic infiltrates in salivary and lacrimal glands. Clinical manifestations range from ocular and oral dryness to vasculitis and severe fatigue. pSS is a disease with heterogeneous symptoms and a variable response to the available treatment. Recently, a key role for Interferon (IFN) type I has been implicated in the pathogenesis of pSS. As type I IFN consists of 17 different subtypes, it cannot be easily assessed using a conventional ELISA. Therefore the expression of type I IFN inducible genes - the so-called type I IFN signature - is assessed in salivary gland tissue and blood from patients as a readout for type I IFN activity. In this review we discuss the potential of type I IFN as a novel biomarker for disease activity, subclassification of patients, prediction of therapy response and most importantly as a target for therapeutic intervention.
Original languageUndefined/Unknown
Pages (from-to)457-467
Number of pages11
JournalExpert Review of Clinical Immunology
Volume10
Issue number4
DOIs
Publication statusPublished - 2014

Research programs

  • EMC MM-02-72-02

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