Ultrasound contrast agents mediated cell labeling for MRI tracking

Research output: Chapter/Conference proceedingConference proceedingAcademicpeer-review

Abstract

In vivo cell tracking is an emerging field and a promising technique for tracking stem cells, metastasis and inflammation. The aim of this study was to find optimal US parameters for ultrasound contrast agent-mediated SPIO-labeling of endothelial cells for MRI tracking. The optimal ultrasound parameters were 40 kPa at 1 MHz, 10,000 cycles, 20 Hz pulse repetition frequency, applied 5 minutes after SPIO addition. This gave a ∼7 times increase of SPIO uptake in endothelial cells in vitro compared to the control with 90% cell viability. This technique could therefore be safely used for labeling of endothelial cells with SPIO for MRI tracking.

Original languageEnglish
Title of host publication2012 IEEE International Ultrasonics Symposium, IUS 2012
Pages2278-2281
Number of pages4
DOIs
Publication statusPublished - 2012
Event2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany
Duration: 7 Oct 201210 Oct 2012

Publication series

SeriesIEEE International Ultrasonics Symposium, IUS
ISSN1948-5719

Conference

Conference2012 IEEE International Ultrasonics Symposium, IUS 2012
Country/TerritoryGermany
CityDresden
Period7/10/1210/10/12

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