Understanding, assessing and treating immune, endothelial and haemostasis dysfunctions in bacterial sepsis

Massimo Girardis; Sascha David; Ricard Ferrer; Julie Helms; Nicole P. Juffermans; Ignacio Martin-Loeches; Pedro Povoa; Lene Russell; Manu Shankar-Hari; Toshiaki Iba; Irene Coloretti; Nicholas Parchim; Nathan D. Nielsen

doi:10.1007/s00134-024-07586-2

Understanding, assessing and treating immune, endothelial and haemostasis dysfunctions in bacterial sepsis

Massimo Girardis^*, Sascha David, Ricard Ferrer, Julie Helms, Nicole P. Juffermans, Ignacio Martin-Loeches, Pedro Povoa, Lene Russell, Manu Shankar-Hari, Toshiaki Iba, Irene Coloretti, Nicholas Parchim, Nathan D. Nielsen

^*Corresponding author for this work

Intensive Care

Research output: Contribution to journal › Review article › Academic › peer-review

18 Citations (Web of Science)

11 Downloads (Pure)

Abstract

The interplay between the immune system, coagulation, and endothelium is critical in regulating the host response to infection. However, in sepsis and other critical illnesses, a dysregulated immune response can lead to excessive alterations in these mechanisms, resulting in coagulopathy, endothelial dysfunction, and multi-organ dysfunction. This review aims to provide a comprehensive analysis of the pathophysiological mechanisms that govern the complex interplay between immune dysfunction, endothelial dysfunction, and coagulation in sepsis. It emphasises clinical significance, evaluation methods, and potential therapeutic interventions. Understanding these mechanisms is essential for developing effective treatments that can modulate the immune response, mitigate thrombosis, restore endothelial function, and ultimately improve patient survival.

Original language	English
Pages (from-to)	1580–1592
Number of pages	13
Journal	Intensive Care Medicine
Volume	50
Issue number	10
DOIs	https://doi.org/10.1007/s00134-024-07586-2
Publication status	Published - Oct 2024

Bibliographical note

Publisher Copyright:
© Springer-Verlag GmbH Germany, part of Springer Nature 2024.

Access to Document

10.1007/s00134-024-07586-2

s00134-024-07586-2Final published version, 1.55 MBLicence: Article 25fa Dutch Copyright Act

Cite this

Girardis, M., David, S., Ferrer, R., Helms, J., Juffermans, N. P., Martin-Loeches, I., Povoa, P., Russell, L., Shankar-Hari, M., Iba, T., Coloretti, I., Parchim, N., & Nielsen, N. D. (2024). Understanding, assessing and treating immune, endothelial and haemostasis dysfunctions in bacterial sepsis. Intensive Care Medicine, 50(10), 1580–1592. https://doi.org/10.1007/s00134-024-07586-2

@article{16ee5b8dd61442849b3023540d973993,

title = "Understanding, assessing and treating immune, endothelial and haemostasis dysfunctions in bacterial sepsis",

abstract = "The interplay between the immune system, coagulation, and endothelium is critical in regulating the host response to infection. However, in sepsis and other critical illnesses, a dysregulated immune response can lead to excessive alterations in these mechanisms, resulting in coagulopathy, endothelial dysfunction, and multi-organ dysfunction. This review aims to provide a comprehensive analysis of the pathophysiological mechanisms that govern the complex interplay between immune dysfunction, endothelial dysfunction, and coagulation in sepsis. It emphasises clinical significance, evaluation methods, and potential therapeutic interventions. Understanding these mechanisms is essential for developing effective treatments that can modulate the immune response, mitigate thrombosis, restore endothelial function, and ultimately improve patient survival.",

author = "Massimo Girardis and Sascha David and Ricard Ferrer and Julie Helms and Juffermans, {Nicole P.} and Ignacio Martin-Loeches and Pedro Povoa and Lene Russell and Manu Shankar-Hari and Toshiaki Iba and Irene Coloretti and Nicholas Parchim and Nielsen, {Nathan D.}",

note = "Publisher Copyright: {\textcopyright} Springer-Verlag GmbH Germany, part of Springer Nature 2024.",

year = "2024",

month = oct,

doi = "10.1007/s00134-024-07586-2",

language = "English",

volume = "50",

pages = "1580–1592",

journal = "Intensive Care Medicine",

issn = "0342-4642",

publisher = "Springer Science+Business Media",

number = "10",

}

Girardis, M, David, S, Ferrer, R, Helms, J, Juffermans, NP, Martin-Loeches, I, Povoa, P, Russell, L, Shankar-Hari, M, Iba, T, Coloretti, I, Parchim, N & Nielsen, ND 2024, 'Understanding, assessing and treating immune, endothelial and haemostasis dysfunctions in bacterial sepsis', Intensive Care Medicine, vol. 50, no. 10, pp. 1580–1592. https://doi.org/10.1007/s00134-024-07586-2

TY - JOUR

T1 - Understanding, assessing and treating immune, endothelial and haemostasis dysfunctions in bacterial sepsis

AU - Girardis, Massimo

AU - David, Sascha

AU - Ferrer, Ricard

AU - Helms, Julie

AU - Juffermans, Nicole P.

AU - Martin-Loeches, Ignacio

AU - Povoa, Pedro

AU - Russell, Lene

AU - Shankar-Hari, Manu

AU - Iba, Toshiaki

AU - Coloretti, Irene

AU - Parchim, Nicholas

AU - Nielsen, Nathan D.

PY - 2024/10

Y1 - 2024/10

N2 - The interplay between the immune system, coagulation, and endothelium is critical in regulating the host response to infection. However, in sepsis and other critical illnesses, a dysregulated immune response can lead to excessive alterations in these mechanisms, resulting in coagulopathy, endothelial dysfunction, and multi-organ dysfunction. This review aims to provide a comprehensive analysis of the pathophysiological mechanisms that govern the complex interplay between immune dysfunction, endothelial dysfunction, and coagulation in sepsis. It emphasises clinical significance, evaluation methods, and potential therapeutic interventions. Understanding these mechanisms is essential for developing effective treatments that can modulate the immune response, mitigate thrombosis, restore endothelial function, and ultimately improve patient survival.

AB - The interplay between the immune system, coagulation, and endothelium is critical in regulating the host response to infection. However, in sepsis and other critical illnesses, a dysregulated immune response can lead to excessive alterations in these mechanisms, resulting in coagulopathy, endothelial dysfunction, and multi-organ dysfunction. This review aims to provide a comprehensive analysis of the pathophysiological mechanisms that govern the complex interplay between immune dysfunction, endothelial dysfunction, and coagulation in sepsis. It emphasises clinical significance, evaluation methods, and potential therapeutic interventions. Understanding these mechanisms is essential for developing effective treatments that can modulate the immune response, mitigate thrombosis, restore endothelial function, and ultimately improve patient survival.

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=eur_pure&SrcAuth=WosAPI&KeyUT=WOS:001303897700003&DestLinkType=FullRecord&DestApp=WOS_CPL

U2 - 10.1007/s00134-024-07586-2

DO - 10.1007/s00134-024-07586-2

M3 - Review article

C2 - 39222142

SN - 0342-4642

VL - 50

SP - 1580

EP - 1592

JO - Intensive Care Medicine

JF - Intensive Care Medicine

IS - 10

ER -

Understanding, assessing and treating immune, endothelial and haemostasis dysfunctions in bacterial sepsis

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this