Given ongoing changes in the world of work that affect both developing and industrialized countries, we argue that it is time to bring the notions of informal and precarious work together. Work-related insecurities offer a conceptual umbrella for the conditions that a large number of workers in the global North and South experience. They emerge in the context of neoliberal globalization, intersecting with social and political marginalizations. This offers starting points for intervention. For instance, for precarious workers’ struggles to be successful, organizational strength needs to be combined with the forging of coalitions that transcend class identities.