Unmet Needs for the Treatment of Chronic Hepatitis E Virus Infection in Immunocompromised Patients

Nassim Kamar; Arnaud Del Bello; Florence Abravanel; Qiuwei Pan; Jacques Izopet

doi:10.3390/v14102116

Unmet Needs for the Treatment of Chronic Hepatitis E Virus Infection in Immunocompromised Patients

Nassim Kamar^*, Arnaud Del Bello, Florence Abravanel, Qiuwei Pan, Jacques Izopet

^*Corresponding author for this work

Gastroenterology & Hepatology

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

30 Downloads (Pure)

Abstract

Hepatitis E virus (HEV) is the most prevalent hepatitis virus worldwide. Genotypes 3 (HEV3) and 4 (HEV4) as well as rat HEV can lead to chronic hepatitis E and cirrhosis in immunosuppressed patients. Within the last decade, several options for treating chronic hepatitis have been developed and have achieved a sustained virological response. However, there are still unmet needs such as optimizing immunosuppression to allow HEV clearance with or without ribavirin, as well as alternative therapies to ribavirin that are discussed in this paper.

Original language	English
Article number	2116
Journal	Viruses
Volume	14
Issue number	10
DOIs	https://doi.org/10.3390/v14102116
Publication status	Published - 25 Sept 2022

Bibliographical note

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/v14102116Licence: CC BY

viruses-14-02116Final published version, 384 KBLicence: CC BY

Cite this

@article{d42bce12231d40a1bb891fb5d36bd64f,

title = "Unmet Needs for the Treatment of Chronic Hepatitis E Virus Infection in Immunocompromised Patients",

abstract = "Hepatitis E virus (HEV) is the most prevalent hepatitis virus worldwide. Genotypes 3 (HEV3) and 4 (HEV4) as well as rat HEV can lead to chronic hepatitis E and cirrhosis in immunosuppressed patients. Within the last decade, several options for treating chronic hepatitis have been developed and have achieved a sustained virological response. However, there are still unmet needs such as optimizing immunosuppression to allow HEV clearance with or without ribavirin, as well as alternative therapies to ribavirin that are discussed in this paper.",

author = "Nassim Kamar and {Del Bello}, Arnaud and Florence Abravanel and Qiuwei Pan and Jacques Izopet",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = sep,

day = "25",

doi = "10.3390/v14102116",

language = "English",

volume = "14",

journal = "Viruses",

issn = "1999-4915",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "10",

}

TY - JOUR

T1 - Unmet Needs for the Treatment of Chronic Hepatitis E Virus Infection in Immunocompromised Patients

AU - Kamar, Nassim

AU - Del Bello, Arnaud

AU - Abravanel, Florence

AU - Pan, Qiuwei

AU - Izopet, Jacques

PY - 2022/9/25

Y1 - 2022/9/25

N2 - Hepatitis E virus (HEV) is the most prevalent hepatitis virus worldwide. Genotypes 3 (HEV3) and 4 (HEV4) as well as rat HEV can lead to chronic hepatitis E and cirrhosis in immunosuppressed patients. Within the last decade, several options for treating chronic hepatitis have been developed and have achieved a sustained virological response. However, there are still unmet needs such as optimizing immunosuppression to allow HEV clearance with or without ribavirin, as well as alternative therapies to ribavirin that are discussed in this paper.

AB - Hepatitis E virus (HEV) is the most prevalent hepatitis virus worldwide. Genotypes 3 (HEV3) and 4 (HEV4) as well as rat HEV can lead to chronic hepatitis E and cirrhosis in immunosuppressed patients. Within the last decade, several options for treating chronic hepatitis have been developed and have achieved a sustained virological response. However, there are still unmet needs such as optimizing immunosuppression to allow HEV clearance with or without ribavirin, as well as alternative therapies to ribavirin that are discussed in this paper.

UR - http://www.scopus.com/inward/record.url?scp=85140848762&partnerID=8YFLogxK

U2 - 10.3390/v14102116

DO - 10.3390/v14102116

M3 - Article

C2 - 36298671

AN - SCOPUS:85140848762

SN - 1999-4915

VL - 14

JO - Viruses

JF - Viruses

IS - 10

M1 - 2116

ER -

Unmet Needs for the Treatment of Chronic Hepatitis E Virus Infection in Immunocompromised Patients

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this