Unmet Needs for the Treatment of Chronic Hepatitis E Virus Infection in Immunocompromised Patients

Nassim Kamar*, Arnaud Del Bello, Florence Abravanel, Qiuwei Pan, Jacques Izopet

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Hepatitis E virus (HEV) is the most prevalent hepatitis virus worldwide. Genotypes 3 (HEV3) and 4 (HEV4) as well as rat HEV can lead to chronic hepatitis E and cirrhosis in immunosuppressed patients. Within the last decade, several options for treating chronic hepatitis have been developed and have achieved a sustained virological response. However, there are still unmet needs such as optimizing immunosuppression to allow HEV clearance with or without ribavirin, as well as alternative therapies to ribavirin that are discussed in this paper.

Original languageEnglish
Article number2116
JournalViruses
Volume14
Issue number10
DOIs
Publication statusPublished - 25 Sep 2022

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